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中耳炎防治进展

Update on otitis media - prevention and treatment.

作者信息

Qureishi Ali, Lee Yan, Belfield Katherine, Birchall John P, Daniel Matija

机构信息

Otolaryngology Head and Neck Surgery, Northampton General Hospital, Northampton, UK.

NIHR Nottingham Hearing Biomedical Research Unit, Nottingham, UK.

出版信息

Infect Drug Resist. 2014 Jan 10;7:15-24. doi: 10.2147/IDR.S39637.

DOI:10.2147/IDR.S39637
PMID:24453496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3894142/
Abstract

Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings remain, and thus better treatments would be welcome. Recent discoveries within the field of otitis media research relating to its etiology and pathogenesis have led to further investigation aimed at developing novel treatments. This article provides a review of the latest evidence relating to the understanding of acute otitis media and otitis media with effusion, current treatment strategies, their limitations, new areas of research, and novel strategies for treatment.

摘要

急性中耳炎和分泌性中耳炎是常见的儿童疾病,是导致显著发病的原因,也是初级卫生保健中抗生素处方的主要原因。尽管有有效的治疗方法,但仍存在一些不足之处,因此更有效的治疗方法将受到欢迎。中耳炎研究领域最近在病因学和发病机制方面的发现促使人们进一步开展研究,以开发新的治疗方法。本文综述了有关急性中耳炎和分泌性中耳炎的最新认识、当前的治疗策略、其局限性、新的研究领域以及新的治疗策略的最新证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/242b/3894142/cd8540fd241d/idr-7-015Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/242b/3894142/958019ff8feb/idr-7-015Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/242b/3894142/cd8540fd241d/idr-7-015Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/242b/3894142/958019ff8feb/idr-7-015Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/242b/3894142/cd8540fd241d/idr-7-015Fig2.jpg

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1
Update on otitis media - prevention and treatment.中耳炎防治进展
Infect Drug Resist. 2014 Jan 10;7:15-24. doi: 10.2147/IDR.S39637.
2
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Clin Infect Dis. 1994 Nov;19(5):823-33. doi: 10.1093/clinids/19.5.823.
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本文引用的文献

1
Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms.遗传易感性与分泌性中耳炎:候选基因单核苷酸多态性。
Laryngoscope. 2014 May;124(5):1229-35. doi: 10.1002/lary.24349. Epub 2013 Oct 2.
2
What is the best practice for acute mastoiditis in children?儿童急性乳突炎的最佳治疗方法是什么?
Laryngoscope. 2014 May;124(5):1057-8. doi: 10.1002/lary.24306. Epub 2013 Dec 31.
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Clinical practice guideline: Tympanostomy tubes in children.临床实践指南:儿童鼓膜置管术。
儿童急性中耳炎的决定因素:印度尼西亚西爪哇的一项病例对照研究
Medicina (Kaunas). 2025 Jan 23;61(2):197. doi: 10.3390/medicina61020197.
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Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa.鼓室内注射地塞米松可减轻辐射所致的中耳黏膜损伤。
Sci Rep. 2025 Jan 24;15(1):3127. doi: 10.1038/s41598-025-87195-1.
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Bacterial etiologies, antimicrobial susceptibility profiles and associated factors among patients with otitis media referred to Nekemte Public Health Research and Referral Laboratory Center, Western Ethiopia: A cross-sectional study.埃塞俄比亚西部内克梅特公共卫生研究与转诊实验室中心收治的中耳炎患者的细菌病因、抗菌药物敏感性概况及相关因素:一项横断面研究。
BMC Microbiol. 2025 Jan 7;25(1):6. doi: 10.1186/s12866-024-03664-z.
6
Clinical and Pathological Characteristics of Chronic Otomastoiditis: A Retrospective Analysis of Risk Factors, Outcomes, and Antibiotic Resistance Patterns.慢性中耳乳突炎的临床与病理特征:危险因素、转归及抗生素耐药模式的回顾性分析
Healthcare (Basel). 2024 Dec 12;12(24):2518. doi: 10.3390/healthcare12242518.
7
Identification of rare missense variants in the BSN gene co-segregating with chronic otitis media in a consanguineous Pakistani family.鉴定一个巴基斯坦血缘家族中与慢性中耳炎共分离的 BSN 基因罕见错义变异。
Mol Genet Genomic Med. 2024 Sep;12(9):e2478. doi: 10.1002/mgg3.2478.
8
Parental Knowledge, Attitudes, and Practices Towards Pediatric Ear Infections in the Makkah Region of Saudi Arabia: A Cross-Sectional Study.沙特阿拉伯麦加地区父母对小儿耳部感染的认知、态度和行为:一项横断面研究。
Cureus. 2024 Jun 9;16(6):e61990. doi: 10.7759/cureus.61990. eCollection 2024 Jun.
9
Exploring the OTITIS Research Landscape Through a Scientometric Approach.通过科学计量学方法探索中耳炎研究领域
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1697-1710. doi: 10.1007/s12070-023-04387-9. Epub 2023 Dec 9.
10
Risk Factors for Chronic and Recurrent Otitis Media in Children: A Review Article.儿童慢性及复发性中耳炎的危险因素:一篇综述文章。
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1464-1469. doi: 10.1007/s12070-023-04256-5. Epub 2023 Oct 12.
Otolaryngol Head Neck Surg. 2013 Jul;149(1 Suppl):S1-35. doi: 10.1177/0194599813487302.
4
Clinical manifestations and microbiology of acute otitis media with spontaneous otorrhea in children.儿童自发性耳漏性急性中耳炎的临床表现和微生物学
J Microbiol Immunol Infect. 2013 Oct;46(5):382-8. doi: 10.1016/j.jmii.2013.04.001. Epub 2013 Jun 10.
5
Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era.西班牙幼儿复发性急性中耳炎(AOM)及AOM治疗失败相关细菌的微生物学研究:肺炎球菌结合疫苗接种后时代的病原体变迁
Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1231-6. doi: 10.1016/j.ijporl.2013.04.002. Epub 2013 Jun 6.
6
Acute otitis media in infants younger than three months not vaccinated against Streptococcus pneumoniae.小于三个月且未接种肺炎链球菌疫苗的婴儿的急性中耳炎
Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):976-80. doi: 10.1016/j.ijporl.2013.03.024. Epub 2013 Apr 17.
7
Panel 6: Vaccines.第六面板:疫苗。
Otolaryngol Head Neck Surg. 2013 Apr;148(4 Suppl):E90-101. doi: 10.1177/0194599812466535.
8
Panel 5: Microbiology and immunology panel.第五小组:微生物学与免疫学小组。
Otolaryngol Head Neck Surg. 2013 Apr;148(4 Suppl):E64-89. doi: 10.1177/0194599812459636.
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Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.小组 4:分子生物学、生物化学、遗传学和动物模型方面中耳炎的最新进展。
Otolaryngol Head Neck Surg. 2013 Apr;148(4 Suppl):E52-63. doi: 10.1177/0194599813479772.
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Panel 3: Recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis.Panel 3:与中耳炎发病机制相关的解剖学、病理学和细胞生物学的最新进展。
Otolaryngol Head Neck Surg. 2013 Apr;148(4 Suppl):E37-51. doi: 10.1177/0194599813476257.