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用于浏览和绘制SomaLogic ADAT文件的网络工具。

Web Tool for Navigating and Plotting SomaLogic ADAT Files.

作者信息

Cheung Foo, Fantoni Giovanna, Conner Maria, Sellers Brian A, Kotliarov Yuri, Candia Julián, Stagliano Katherine, Biancotto Angélique

机构信息

Trans-NIH Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD 20892, US.

出版信息

J Open Res Softw. 2017;5. doi: 10.5334/jors.166. Epub 2017 Sep 8.

Abstract

SOMAscan™ is a complex proteomic platform created by SomaLogic. Experimental data resulting from the assay is provided by SomaLogic in a proprietary text-based format called ADAT. This manuscript describes a user-friendly point and click open source, platform-independent software tool designed to be used for navigating and plotting data from an ADAT file. This tool was used either alone or in conjunction with other tools as a first pass analysis of the data on several different on-going research projects. We have seen a need from our experience for a web interface to the ADAT file so that users can navigate, generate plots, perform QC and conduct statistical analysis on their own data in a point and click manner. After several rounds of interacting with biologists and their requirements with respect to data analysis, we present an online interactive Shiny Web Tool for Navigating and Plotting data contained within the ADAT file. Extensive video tutorials, example data, the tool and the source code are available online.

摘要

SOMAscan™是SomaLogic创建的一个复杂蛋白质组学平台。该检测产生的实验数据由SomaLogic以一种专有的基于文本的格式ADAT提供。本文描述了一个用户友好的、通过点击操作的开源、平台独立的软件工具,旨在用于浏览和绘制来自ADAT文件的数据。该工具单独使用或与其他工具结合使用,作为对几个不同正在进行的研究项目的数据的初步分析。根据我们的经验,我们发现需要一个用于ADAT文件的网络界面,以便用户能够以点击操作的方式浏览、生成图表、执行质量控制并对自己的数据进行统计分析。在与生物学家就数据分析及其需求进行了几轮互动之后,我们展示了一个用于浏览和绘制ADAT文件中包含的数据的在线交互式Shiny网络工具。大量的视频教程、示例数据、该工具及其源代码均可在线获取。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36da/6017986/d7e24d10e8b3/nihms932323f1.jpg

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