A Mahmoudi, M B Shojaeifard, S Nematollahii, S M J Mortazavi, A R Mehdizadeh
Medical Student, Shiraz University of Medical Sciences, Shiraz, Iran.
Physiology Department, Fasa University of Medical Sciences, Fasa, Iran.
J Biomed Phys Eng. 2018 Jun 1;8(2):185-192. eCollection 2018 Jun.
Electromagnetic fields (EMF) with different intensities are widely used at home, offices and public places.Today, there is a growing global concern about the effects of human exposure to EMFs. Epilepsy is one of the most common chronic neurological diseases, affecting 50 million people of all ages worldwide. We aimed to investigate the effect of exposure to Wi-Fi radiation on epileptic behavior of rats.
147 male rats, weighing 200-250 g, were divided into seven groups; negative control (no intervention), sham 1(distilled water), positive control (Pentylentetrazol [PTZ]), intervention group 1 (PTZ + Wi-Fi "off"), sham 2 (distilled water + Wi-Fi "off"), sham 3 (distilled water + Wi-Fi "on"), and intervention group 2 (PTZ + Wi-Fi "on"). The rats were exposed to Wi-Fi for 2h at a distance of 30cm from a commercial Wi-Fi router. Convulsive behaviors of rats were monitored and scored based on the intensity and type by measuring latency/threshold time, number of convulsions, sum of scores and durations of seizure, and duration of score 6 seizure. Kruskal-Wallis and Mann-Whitney U-tests were used to analyze the data.
Convulsion was observed in interventions Group 4 and Group 7, and positive control. The mean number of events, and sum of scores were significantly different in intervention 2 than other two groups. However, the differences in mean threshold, mean sum of durations and " time to show convulsion with score 6 " were not statistically significant (P>0.05).
Due to limitations of our study including the sample size, these findings should be interpreted with caution. In this study, exposure to 2.4 GHz Wi-Fi radiation showed significant beneficial effects on the epileptic behaviour of rats. More experiments are needed to verify if these exposures can be used as a therapeutic approach for amelioration of seizures in epilepsy.
不同强度的电磁场（EMF）在家庭、办公室和公共场所广泛使用。如今，全球对人类暴露于电磁场的影响日益关注。癫痫是最常见的慢性神经系统疾病之一，全球所有年龄段有5000万人受其影响。我们旨在研究暴露于Wi-Fi辐射对大鼠癫痫行为的影响。
147只体重200 - 250克的雄性大鼠被分为七组；阴性对照组（无干预）、假手术1组（蒸馏水）、阳性对照组（戊四氮[PTZ]）、干预组1（PTZ + Wi-Fi“关闭”）、假手术2组（蒸馏水 + Wi-Fi“关闭”）、假手术3组（蒸馏水 + Wi-Fi“开启”）和干预组2（PTZ + Wi-Fi“开启”）。大鼠在距离商用Wi-Fi路由器30厘米处暴露于Wi-Fi 2小时。通过测量潜伏期/阈值时间、惊厥次数、分数总和、癫痫发作持续时间以及6分癫痫发作持续时间，根据强度和类型对大鼠的惊厥行为进行监测和评分。采用Kruskal-Wallis和Mann-Whitney U检验分析数据。
在干预组4、7以及阳性对照组中观察到惊厥。干预组2的平均事件数和分数总和与其他两组有显著差异。然而，平均阈值、平均持续时间总和以及“出现6分惊厥的时间”的差异无统计学意义（P>0.05）。
由于本研究存在包括样本量在内的局限性，这些发现应谨慎解读。在本研究中，暴露于2.4 GHz Wi-Fi辐射对大鼠的癫痫行为显示出显著的有益影响。需要更多实验来验证这些暴露是否可作为改善癫痫发作的治疗方法。
