增强子 RNA 在基因调控和癌症中重要作用的最新进展。
Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer.
机构信息
Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.
Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518000, Guangdong, China.
出版信息
Biomed Res Int. 2018 May 22;2018:2405351. doi: 10.1155/2018/2405351. eCollection 2018.
Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development.
揭示调控癌症发生和发展的基因调控网络是必要的，但目前这项工作尚未完成。近年来，已有研究报道增强子广泛转录，产生增强子 RNA（eRNA）。先前的研究表明，eRNA 是长链非编码 RNA（lncRNA）的一个亚类，在基因调控和癌症发生中发挥着关键作用。这些 eRNA 可以通过与其他蛋白因子结合促进增强子-启动子（E-P）环的形成，或促进下游蛋白编码基因的表达。在本综述中，我们重点介绍了 eRNA 的特征，并阐述了 eRNA 调节基因表达和癌症发生的生物学功能和潜在机制。
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