Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), P.O.B. 10 19 49, 69009, Heidelberg, Germany.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Support Care Cancer. 2019 Jan;27(1):275-286. doi: 10.1007/s00520-018-4317-8. Epub 2018 Jun 27.
Many long-term cancer survivors still have to adjust to possible adverse consequences of the illness or treatment. Resources can play an important role in this adjustment process, but research on this topic is limited, especially for very long-term survivors. This study explores, which resources are most frequently indicated by different subgroups of cancer survivors, and what role resources play for functioning and health-related quality of life (HRQL) in cancer survivors with and without recurrence.
The sample of 6030 breast, colorectal, and prostate cancer survivors (5-16 years post-diagnosis) was recruited in a German multi-regional population-based study. Personal resources were assessed by a 27-item checklist; HRQL was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). General linear models were used to analyze associations of resources with HRQL.
Participants indicated on average 11.4 (SD 5.1) resources as helpful. Family, activities with others, and partnership were indicated most commonly overall, but frequencies varied according to age, sex, and tumor site. Physical activity, health, professional help, calmness, hope, optimism, and hobbies were most important in explaining HRQL variance. Cancer survivors with recurrence and many resources were found to report similar HRQL as survivors without recurrence and only few resources.
The study underlines the importance and situational variability of personal and social resources for cancer survivors' HRQL, even years post-diagnosis. Not only the availability, but also the individual perception and significance of resources should be considered in follow-up cancer care.
许多长期癌症幸存者仍需要适应疾病或治疗可能带来的不良后果。资源在这一调整过程中可以发挥重要作用，但关于这个主题的研究有限，尤其是对于非常长期的幸存者。本研究探讨了不同癌症幸存者亚组最常提到的资源是什么，以及资源在有无复发的癌症幸存者的功能和健康相关生活质量（HRQL）中扮演什么角色。
在一项德国多区域基于人群的研究中，招募了 6030 名乳腺癌、结直肠癌和前列腺癌幸存者（诊断后 5-16 年）作为样本。个人资源通过 27 项清单评估；HRQL 通过欧洲癌症研究与治疗组织生活质量问卷核心 30 项（EORTC QLQ-C30）评估。使用一般线性模型分析资源与 HRQL 的关联。
参与者平均表示有 11.4（SD=5.1）项资源是有帮助的。家庭、与他人的活动和伴侣关系总体上被认为是最常见的，但频率因年龄、性别和肿瘤部位而异。体育活动、健康、专业帮助、平静、希望、乐观和爱好是解释 HRQL 差异的最重要因素。研究发现，有复发和许多资源的癌症幸存者报告的 HRQL 与无复发且只有少数资源的幸存者相似。
本研究强调了个人和社会资源对癌症幸存者 HRQL 的重要性和情境可变性，即使在诊断后多年也是如此。在后续癌症护理中，不仅要考虑资源的可获得性，还要考虑个体对资源的感知和重要性。
