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[α-半乳糖相关的迟发性红肉过敏症作为一种职业病]

[Alpha-Gal-associated delayed red meat anaphylaxis as an occupational disease].

作者信息

Anemüller W, Mohr M, Brans R, Homann A, Jappe U

机构信息

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Lübeck, Deutschland.

Institut für Gesundheitsforschung und Bildung (IGB), Abteilung Dermatologie, Umweltmedizin und Gesundheitstheorie, Institut für interdisziplinäre Dermatologische Prävention und Rehabilitation (iDerm), Universität Osnabrück, Osnabrück, Deutschland.

出版信息

Hautarzt. 2018 Oct;69(10):848-852. doi: 10.1007/s00105-018-4224-4.

Abstract

In a 30-year-old chef with recurrent delayed angioedema history as well as the experimental detection of IgE antibodies against galactose-alpha-(1,3)-galactose (alpha-Gal) pointed to alpha-Gal as the causative agent. The diagnosis, therefore, was delayed anaphylaxis due to alpha-Gal. Because of the potential relationship to his profession, we submitted a dermatologist's report BK 5101 to the liability and insurance association, whereupon his contract of employment was terminated without notice. As a consequence, we reported an occupational disease. This case demonstrates an underdiagnosed, potentially life-threatening allergy to the disaccharide alpha-Gal in red meat as an occupational disease.

摘要

一名30岁的厨师有复发性迟发性血管性水肿病史,且实验检测发现其体内存在针对半乳糖-α-(1,3)-半乳糖(α-Gal)的IgE抗体,这表明α-Gal是致病因素。因此,诊断为α-Gal所致的迟发性过敏反应。鉴于其职业与该病的潜在关联,我们向责任与保险协会提交了皮肤科医生报告BK 5101,随后他的雇佣合同被无故终止。结果,我们报告了一例职业病。该病例表明,红肉中作为职业病的二糖α-Gal所致的过敏反应诊断不足,可能危及生命。

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