Department of Epidemiology, Fukushima Medical University School of Medicine.
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine.
Circ J. 2018 Jul 25;82(8):2063-2070. doi: 10.1253/circj.CJ-18-0040. Epub 2018 Jun 27.
Numerous studies have reported the association of cardiovascular risk factors with pulmonary embolism (PE), but the association of dietary factors, especially fish intake, with the risk of PE has not been fully established.
Using a prospective design, we studied the risk of PE mortality in relation to fish intake in 90,791 community-dwelling men and women in Japan aged 40-79 years. The hazard ratios (HRs) and 95% confidence intervals (CIs) for PE death were estimated using the Cox proportional hazards model. Compared with participants in the lowest fresh fish intake group (<1 time/month), the HRs (95% CIs) for PE death for those in the other intake groups were 0.35 (0.08-1.59) for 1-2 times/month, 0.19 (0.05-0.69) for 1-2 times/week, 0.20 (0.06-0.74) for 3-4 times/week, and 0.18 (0.05-0.66) for fish intake every day. In addition to these findings, compared with the participants in the lowest 10% of ω3 polyunsaturated fatty acid intake, those in the other groups had a 60-76% lower risk of PE death.
Fresh fish intake, even 1-2 times/week, is associated with a lower risk of death from PE among Japanese men and women.
许多研究报告了心血管危险因素与肺栓塞（PE）的相关性，但饮食因素，尤其是鱼类摄入量与 PE 风险的相关性尚未完全确定。
我们采用前瞻性设计，研究了日本 90791 名 40-79 岁社区居民中与鱼类摄入量相关的 PE 死亡风险。使用 Cox 比例风险模型估计 PE 死亡的风险比（HR）和 95%置信区间（CI）。与最低新鲜鱼摄入量组（<1 次/月）的参与者相比，其他摄入量组的 PE 死亡 HR（95%CI）分别为 1-2 次/月为 0.35（0.08-1.59），1-2 次/周为 0.19（0.05-0.69），3-4 次/周为 0.20（0.06-0.74），每天摄入鱼类为 0.18（0.05-0.66）。除了这些发现，与ω3 多不饱和脂肪酸摄入量最低的 10%的参与者相比，其他组的 PE 死亡风险降低了 60-76%。
即使每周食用 1-2 次新鲜鱼类，也与日本男性和女性的 PE 死亡风险降低相关。
