Zhang Yi, Ding Jun, Guo Hongbin, Liang Jieyu, Li Yusheng
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Changsha Social Work College, Changsha, China.
Front Nutr. 2020 Dec 17;7:614784. doi: 10.3389/fnut.2020.614784. eCollection 2020.
This study aims to investigate the effect of fish and omega-3 fatty acids consumption on the risk of VTE. A comprehensive literature search in the databases of PubMed, Web of Science, and Embase (up to September 2020), was conducted to identify the prospective cohort studies concerning the associations of fish and omega-3 fatty acids consumption with the risk of VTE. The pooled relative risk (RR) of VTE for the highest vs. lowest category of fish and omega-3 fatty acids consumption, as well as their corresponding 95% confidence interval (CI) were calculated. A total of seven articles with eight prospective cohort studies were included. Specifically, six studies were related to fish consumption, and the overall multi-variable adjusted RR showed no significant relationship between fish consumption and the risk of VTE (RR = 1.02, 95% CI: 0.93-1.11; = 0.709). In the four studies related to omega-3 fatty acids consumption, the overall multi-variable adjusted RR suggested that omega-3 fatty acids consumption was associated with a lower risk of VTE (RR = 0.89, 95% CI: 0.80-0.98; = 0.024). Moreover, two studies were related to recurrent VTE, and the overall multi-variable adjusted RR demonstrated a significant inverse association between omega-3 fatty acids consumption and the risk of recurrent VTE (RR = 0.45, 95% CI: 0.25-0.81; = 0.008). Although current evidence is still insufficient to demonstrate any relationship between fish consumption and the risk of VTE, omega-3 fatty acids consumption seems to be associated with a lower risk of both VTE and recurrent VTE. Further large well-designed prospective cohort studies are warranted to elaborate the issues examined in this study.
本研究旨在调查食用鱼类和ω-3脂肪酸对静脉血栓栓塞（VTE）风险的影响。我们在PubMed、科学网和Embase数据库（截至2020年9月）中进行了全面的文献检索，以确定有关食用鱼类和ω-3脂肪酸与VTE风险之间关联的前瞻性队列研究。计算了鱼类和ω-3脂肪酸摄入量最高组与最低组的VTE合并相对风险（RR）及其相应的95%置信区间（CI）。共纳入了7篇包含8项前瞻性队列研究的文章。具体而言，6项研究与鱼类消费有关，总体多变量调整后的RR显示鱼类消费与VTE风险之间无显著关系（RR = 1.02，95% CI：0.93 - 1.11；P = 0.709）。在4项与ω-3脂肪酸消费有关的研究中，总体多变量调整后的RR表明，食用ω-3脂肪酸与较低的VTE风险相关（RR = 0.89，95% CI：0.80 - 0.98；P = 0.024）。此外，2项研究与复发性VTE有关，总体多变量调整后的RR表明，食用ω-3脂肪酸与复发性VTE风险之间存在显著的负相关（RR = 0.45，95% CI：0.25 - 0.81；P = 0.008）。尽管目前的证据仍不足以证明鱼类消费与VTE风险之间存在任何关系，但食用ω-3脂肪酸似乎与较低的VTE和复发性VTE风险相关。有必要进行进一步大规模的精心设计的前瞻性队列研究，以阐明本研究中所探讨的问题。
