a Institute of Military Cognition and Brain Sciences , Beijing , China.
b College of Pharmaceutical Sciences , Hebei University , Baoding , China.
J Drug Target. 2019 Mar;27(3):283-291. doi: 10.1080/1061186X.2018.1486406. Epub 2018 Jul 17.
Oral delivery is the most common method of drug administration with high safety and good compliance for patients. However, delivering therapeutic proteins to the target site via oral route involves tremendous challenge due to unfavourable conditions like biochemical barrier, mucus barrier and epithelial barriers. According to the functional differences of various protein drug delivery systems, the recent advances in pH responsive polymer-based drug delivery system, mucoadhesive polymer-based drug delivery system, absorption enhancers-based drug delivery system and composite polymer-based delivery system all were briefly summarised in this review, which not only clarified the clinic potential of these novel drug delivery systems, but also described the way for increasing oral bioavailability of therapeutic protein.
口服是最常见的给药方式，具有较高的安全性和患者顺应性。然而，由于生化屏障、黏液屏障和上皮屏障等不利条件，通过口服途径将治疗性蛋白质递送到靶部位仍然具有巨大的挑战。根据各种蛋白质药物传递系统的功能差异，本文简要总结了 pH 响应聚合物基药物传递系统、黏附聚合物基药物传递系统、吸收增强剂基药物传递系统和复合聚合物基传递系统的最新进展，不仅阐明了这些新型药物传递系统的临床潜力，还描述了提高治疗性蛋白质口服生物利用度的方法。
