Mertins Omar, Mathews Patrick D, Angelova Angelina
Institut Galien Paris-Saclay UMR8612, Université Paris-Saclay, CNRS, F-92296 Châtenay-Malabry, France.
Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, Brazil.
Nanomaterials (Basel). 2020 May 18;10(5):963. doi: 10.3390/nano10050963.
Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs' bioavailability.
纳米结构双连续立方相自组装材料作为生物相容性递送系统在各种治疗领域的应用正在不断拓展。通过pH敏感脂质和/或pH敏感聚合物壳对立方液晶、海绵液晶、六方液晶和脂质体纳米载体进行功能化，为新一代癌症治疗的口服和局部给药提供了新机遇。药物化合物的电化学行为也可能有利于pH触发的药物释放。在此，我们重点介绍了最近的一些研究，这些研究探索了混合非层状脂质/脂肪酸或磷脂体系的相行为，以设计具有缓释特性的pH响应性和粘膜粘附性药物递送系统。X射线衍射和小角X射线散射（SAXS）技术通过对脂质/共脂质/水相图中多种两亲性成分进行详细的结构分析，广泛应用于创新递送组件的开发。对于诸如治疗性蛋白质和肽以及难溶性物质的口服递送等具有挑战性的治疗应用，需要pH响应性纳米级材料和纳米颗粒。具有智能立方液晶纳米载体的前瞻性纳米医学发展可能会利用精心设计的组合物来克服肠道障碍，采用双药负载的pH敏感液晶结构以提高治疗效果，以及采用复合（脂质/聚电解质）类型的粘膜粘附控释胶体立方液晶制剂来提高药物的生物利用度。
