Choi Chi-Young, Cho Nam-Jun, Park Samel, Gil Hyo Wook, Kim Yun-Sook, Lee Eun Young
Department of Internal Medicine Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Korea.
Medicine (Baltimore). 2018 Jun;97(26):e11148. doi: 10.1097/MD.0000000000011148.
Currently, 15% of women in fertility age are infertile and the frequency is increasing. Among the various causes of infertility, end-stage renal disease (ESRD) has been shown to decrease the frequency of pregnancies compared with normal females. However, dialysis of patients with ESRD increases the likelihood of pregnancy.Herein, we report successful pregnancy and delivery after peritoneal dialysis in a patient who was misdiagnosed as primary infertility.
A 37-year-old female who was unaware of her ESRD was misdiagnosed with primary infertility. After undergoing artificial insemination, she was referred to department of internal medicine because of generalized edema, dyspnea, nausea, vomiting, and poor oral intake. After evaluation, she was diagnosed with ESRD and initiated peritoneal dialysis.
The patients was on peritoneal dialysis for a year and discovered that she was pregnant.
During pregnancy, the patient maintained a residual urine output, BUN levels below 50 mg/dL, controlled blood pressure and a targeted hemoglobin range. She obtained adequate calories and protein and was managed by a multidisciplinary team.
The patient delivered a preterm male baby with no anomalies.
ESRD should also be considered among the several causes of infertility in fertile women. If ESRD is the cause of infertility, the frequency of pregnancy increases following dialysis. If pregnancy is diagnosed early, intensive renal replacement therapy, adequate nutritional intake and regular fetal monitoring during pregnancy increase the chances of successful delivery while maintaining PD.
目前,育龄期女性中有15%存在不孕问题,且这一比例正在上升。在不孕的各种原因中,终末期肾病(ESRD)已被证明与正常女性相比会降低怀孕几率。然而,ESRD患者进行透析会增加怀孕的可能性。在此,我们报告一例被误诊为原发性不孕的患者在腹膜透析后成功怀孕并分娩的病例。
一名37岁女性,此前未意识到自己患有ESRD,被误诊为原发性不孕。在接受人工授精后,她因全身水肿、呼吸困难、恶心、呕吐及食欲不佳被转诊至内科。经评估,她被诊断为ESRD并开始接受腹膜透析。
该患者接受腹膜透析一年后发现自己怀孕了。
在怀孕期间,患者维持残余尿量,尿素氮水平低于50mg/dL,控制血压并将血红蛋白维持在目标范围内。她摄入了足够的热量和蛋白质,并由多学科团队进行管理。
患者分娩出一名无异常的早产男婴。
在育龄女性不孕的多种原因中也应考虑ESRD。如果ESRD是不孕的原因,透析后怀孕几率会增加。如果早期诊断出怀孕,在维持腹膜透析的同时,强化肾脏替代治疗、充足的营养摄入和孕期定期的胎儿监测可增加成功分娩的机会。