Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
J Cell Biochem. 2018 Nov;119(11):9254-9260. doi: 10.1002/jcb.27194. Epub 2018 Jun 28.
There is some controversy as for the roles played by tumor growth factor-β (TGF-β), interleukin-1β (IL-1β), and IL-22 in the onset process of type 2 diabetes (T2D). The main aim of this project was to examine serum levels of TGF-β, IL-1β, and IL-22 in the new cases and long period T2D patients as well as healthy controls. In this study, 115 new T2D patient cases (group 1), 434 T2D patients who have suffered from the disease more than 2 years (group 2), and 104 healthy controls have been selected from 6240 (3619 females) patients who were under study population from Kerman Coronary Artery Disease Risk Factor Study. Serum levels of TGF-β, IL-1β, and IL-22 have been evaluated using commercial kits. Serum levels of TGF-β and IL-1β significantly increased, while IL-22 decreased in 2 groups in comparison to healthy controls. Serum levels of IL-22, but not TGF-β and IL-1β, were significantly decreased in group 1 in comparison to healthy controls. There were no significant differences between groups 1 and 2 as for the cytokine levels. Serum levels of IL-22 increased in the females in group 2 when compared to females in group 1. It appears that TGF-β and IL-1β participate in the induction of inflammation after establishment of T2D, while decrease in IL-22 may be considered as a key factor for onset of the disease. Gender can also be considered as the main risk factor for variation in cytokine levels.
关于肿瘤生长因子-β（TGF-β）、白细胞介素-1β（IL-1β）和白细胞介素-22（IL-22）在 2 型糖尿病（T2D）发病过程中所起的作用存在一些争议。本项目的主要目的是检测新诊断的 T2D 患者和长期 T2D 患者以及健康对照者血清中 TGF-β、IL-1β 和 IL-22 的水平。本研究从 6240 例（3619 例女性）研究人群中选择了 115 例新诊断的 T2D 患者（第 1 组）、434 例患病 2 年以上的 T2D 患者（第 2 组）和 104 例健康对照者。采用商业试剂盒检测 TGF-β、IL-1β 和 IL-22 的血清水平。与健康对照组相比，第 1 组和第 2 组的 TGF-β 和 IL-1β 血清水平显著升高，而 IL-22 血清水平降低。与健康对照组相比，第 1 组的 IL-22 血清水平显著降低，但 TGF-β 和 IL-1β 血清水平无差异。第 1 组和第 2 组之间的细胞因子水平无显著差异。与第 1 组女性相比，第 2 组女性的 IL-22 血清水平升高。TGF-β 和 IL-1β 可能参与了 T2D 发生后的炎症诱导，而 IL-22 的减少可能被认为是发病的关键因素。性别也可能是细胞因子水平变化的主要危险因素。
