a School of International Liberal Studies, Chukyo University, 101-2 Yagotohonmachi, Showa-ku, Nagoya, 466-8666, Japan.
b Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, Kita-ku, Tokyo, 115-0056, Japan.
Appl Physiol Nutr Metab. 2019 Jan;44(1):47-51. doi: 10.1139/apnm-2018-0355. Epub 2018 Jun 28.
High-intensity interval training (HIIT) is known to be an effective exercise training regimen to improve energy substrate metabolism and insulin sensitivity. However, the underlying mechanisms of improvement in insulin sensitivity due to HIIT have not yet been fully clarified. C1q/tumor necrosis factor-related protein (CTRP) 1 and CTRP9, which are adiponectin paralogs and novel adipokines, have favorable effects on energy substrate metabolism and insulin sensitivity. The purpose of this study was to investigate the effects of a single bout of HIIT on CTRP1 and CTRP9 secretions in healthy men. Eight healthy male subjects (mean ± SE: age, 23.4 ± 1.1 years; height, 172.1 ± 1.7 cm; body mass, 68.0 ± 2.0 kg; body mass index, 22.9 ± 0.5 kg/m) participated in this study. They performed a single bout of HIIT consisted of four 30-s maximal cycling bouts with 4 min of rest between bouts using a cycle ergometer. Blood samples were collected before the exercise, at 0 (immediately after the exercise), 15, 30, and 120 min after the single bout of HIIT. Serum CTRP1, CTRP9, and high-molecular-weight (HMW) adiponectin concentrations were measured using enzyme-linked immunosolvent assay kits. CTRP1 concentration significantly increased at 120 min after the HIIT. CTRP9 concentration also significantly increased immediately after the single bout of HIIT. In contrast, there were no significant differences in HMW adiponectin concentration before and after the acute HIIT. These findings suggest that a single bout of HIIT may stimulate CTRP1 and CTRP9 secretions in healthy men.
高强度间歇训练（HIIT）被认为是一种有效的运动训练方案，可改善能量底物代谢和胰岛素敏感性。然而，由于 HIIT 导致胰岛素敏感性改善的潜在机制尚未完全阐明。C1q/肿瘤坏死因子相关蛋白（CTRP）1 和 CTRP9 是脂联素的旁系同源物和新型脂肪因子，对能量底物代谢和胰岛素敏感性有有利影响。本研究的目的是探讨单次 HIIT 对健康男性中 CTRP1 和 CTRP9 分泌的影响。八名健康男性受试者（平均±SE：年龄 23.4±1.1 岁；身高 172.1±1.7cm；体重 68.0±2.0kg；体重指数 22.9±0.5kg/m）参加了本研究。他们使用自行车测力计进行了一次 HIIT，包括四个 30 秒的最大骑行回合，回合之间休息 4 分钟。在运动前、运动后 0（运动后立即）、15、30 和 120 分钟采集血样。使用酶联免疫吸附测定试剂盒测量血清 CTRP1、CTRP9 和高分子量（HMW）脂联素浓度。HIIT 后 120 分钟，CTRP1 浓度显著升高。单次 HIIT 后，CTRP9 浓度也显著升高。相比之下，急性 HIIT 前后 HMW 脂联素浓度没有差异。这些发现表明，单次 HIIT 可能会刺激健康男性的 CTRP1 和 CTRP9 分泌。
