Duan Ziqiang, Yang Yang, Qin Mianhong, Yi Xuejie
School of Sports Health, Shenyang Sport University, Shenyang, China.
School of Kinesiology, Shanghai University of Sport, Shanghai, China.
J Cell Mol Med. 2024 Nov;28(22):e70136. doi: 10.1111/jcmm.70136.
Interleukin-15 (IL-15), a pro-inflammatory cytokine, is produced mainly by skeletal muscle cells, macrophages and epithelial cells. Recent research has demonstrated that IL-15 is closely related to the functions of bone and skeletal muscle in the locomotor system. There is growing evidence that exercise, an important means to regulate the immune and locomotor systems, influences IL-15 content in various tissues, thereby indirectly affecting the function of bones and muscles. Furthermore, the form, intensity, and duration of exercise determine the degree of change in IL-15 and downstream effects. This paper reviews the structure, synthesis and secretion of IL-15, the role of IL-15 in regulating the metabolism of bone tissue cells and myofibers through binding to the IL-15 receptor-α (IL-15Rα), and the response of IL-15 to different types of exercise. This review provides a reference for further analyses of the role and mechanism of action of IL-15 in the regulation of metabolism during exercise.
白细胞介素-15（IL-15）是一种促炎细胞因子，主要由骨骼肌细胞、巨噬细胞和上皮细胞产生。最近的研究表明，IL-15与运动系统中骨骼和骨骼肌的功能密切相关。越来越多的证据表明，运动作为调节免疫和运动系统的重要手段，会影响各种组织中IL-15的含量，从而间接影响骨骼和肌肉的功能。此外，运动的形式、强度和持续时间决定了IL-15的变化程度及其下游效应。本文综述了IL-15的结构、合成与分泌，IL-15通过与IL-15受体α（IL-15Rα）结合在调节骨组织细胞和肌纤维代谢中的作用，以及IL-15对不同类型运动的反应。本综述为进一步分析IL-15在运动代谢调节中的作用及作用机制提供参考。
