依托考昔和双氯芬酸可能降低骨关节炎患者患痴呆症的风险：一项基于全国人群的回顾性队列研究。
Etoricoxib and Diclofenac Might Reduce the Risk of Dementia in Patients with Osteoarthritis: A Nation-Wide, Population-Based Retrospective Cohort Study.
作者信息
Xue Yu-Hao, Peng Yu-Shin, Ting Hsin-Fu, Peijer Hsieh Jason, Huang Yu-Kai, Wang Yu-Hsun, Chiou Jeng-Yuan, Wei James Cheng-Chung
机构信息
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
出版信息
Dement Geriatr Cogn Disord. 2018;45(5-6):262-271. doi: 10.1159/000485176. Epub 2018 Jun 28.
INTRODUCTION
This population-based cohort study investigates the association between osteoarthritis (OA) and dementia as well as the connection between NSAIDs and dementia.
METHODS
We chose the samples from the Taiwan Longitudinal Health Insurance Database and then divided them into two groups, which were then matched 1: 1 by propensity score. The first group was the OA group that contained patients with newly diagnosed OA and the second group was the non-OA group. We used the χ2 test, Student t test, Kaplan-Meier analysis, and Cox proportional hazard model for different purposes.
RESULTS
The prevalence of dementia in the OA group was higher than that in the non-OA group. The adjusted hazard ratio of the former was 1.42 (95% CI, 1.30-1.54). We also found that etoricoxib and diclofenac might reduce the incidence of dementia.
CONCLUSION
Patients with OA might have a higher risk of dementia. Both etoricoxib and diclofenac might lower the risk of dementia in patients with OA.
引言
这项基于人群的队列研究调查了骨关节炎（OA）与痴呆症之间的关联以及非甾体抗炎药（NSAIDs）与痴呆症之间的联系。
方法
我们从台湾纵向健康保险数据库中选取样本，然后将其分为两组，并按倾向得分进行1:1匹配。第一组是OA组，包含新诊断为OA的患者，第二组是非OA组。我们针对不同目的使用了χ2检验、学生t检验、Kaplan-Meier分析和Cox比例风险模型。
结果
OA组中痴呆症的患病率高于非OA组。前者的调整后风险比为1.42（95%CI，1.30 - 1.54）。我们还发现依托考昔和双氯芬酸可能会降低痴呆症的发病率。
结论
OA患者患痴呆症的风险可能更高。依托考昔和双氯芬酸都可能降低OA患者患痴呆症的风险。
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