Kase Adam M, Menke David, Tan Winston
Department of Internal Medicine, Mayo Clinic's Campus in Florida, Jacksonville, Florida, USA.
Department of Pathology, Mayo Clinic's Campus in Florida, Jacksonville, Florida, USA.
BMJ Case Rep. 2018 Jun 28;2018:bcr-2017-222031. doi: 10.1136/bcr-2017-222031.
Given the prevalence of breast cancer and the mortality associated with metastatic disease, it is imperative for physicians to not only be aware of common sites but also of rare metastatic destinations such as the bladder. A postmenopausal woman with a medical history of stage 2 invasive ductal carcinoma, oestrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 negative, in remission for 9 years, presented to her primary care physician with concerns of increased urinary urgency, frequency and incontinence. The patient underwent cystoscopy with biopsy of an area of granulation tissue. Biopsy revealed adenocarcinoma consistent with breast primary. The common sites of metastases from breast cancer are lung, bone and liver. This case is unique where breast cancer was found to metastasise to the bladder. It is important for physicians to consider further investigation when a breast cancer survivor develops urinary symptoms even without haematuria.
鉴于乳腺癌的发病率以及与转移性疾病相关的死亡率,医生不仅必须了解常见的转移部位,还应知晓诸如膀胱等罕见的转移目的地。一位绝经后女性,有2期浸润性导管癌病史,雌激素受体/孕激素受体阳性,人表皮生长因子受体2阴性,缓解9年,因尿急、尿频和尿失禁加重就诊于她的初级保健医生。患者接受了膀胱镜检查并对肉芽组织区域进行了活检。活检显示腺癌,与乳腺原发癌一致。乳腺癌常见的转移部位是肺、骨和肝。该病例独特之处在于发现乳腺癌转移至膀胱。对于乳腺癌幸存者,即使没有血尿,出现泌尿系统症状时医生考虑进一步检查很重要。