Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Arthritis Research Canada, Milan Ilich Arthritis Research Centre, Richmond, Canada.
Rheumatology (Oxford). 2018 Oct 1;57(10):1789-1794. doi: 10.1093/rheumatology/key164.
To evaluate compliance with hyperlipidaemia screening guidelines for cardiovascular disease prevention in RA compared with the general population.
We conducted a longitudinal study of a population-based RA cohort including all prevalent cases in British Columbia between 1996 and 2006, followed up until 2010, with matched general population controls. Using administrative data, we measured compliance with general population guidelines (testing lipids every 5 years for women ⩾50 and men ⩾40), after excluding individuals with previous diabetes, coronary artery disease or hyperlipidaemia. Compliance was measured as the proportion of 5-year eligibility periods with one or more lipid test. Compliance rates in RA and controls were compared by Chi-square test. Odds ratio (95% CI) of compliance in RA (vs controls) was estimated using generalized estimating equation models, adjusting for age and sex. Mean compliance rate per patient was also calculated and compared using Mann-Whitney U test.
Analyses included 5587 RA individuals and 5613 controls, contributing 6993 and 7208 5-year eligibility periods, respectively. Lipids were measured in 56.6 and 59.5% of eligibility periods in RA and controls, respectively [adjusted odds ratio (95% CI): 0.97 (0.90, 1.06)]. Screening improved over time in RA relative to the general population, but remained suboptimal even after 2003, at 65.8%. Mean (s.d.) compliance rate per patient was 56.6 (47.2)% for RA and 59.5 (46.6)% for controls. Family physicians ordered almost all the lipid tests.
Compliance with general population guidelines for hyperlipidaemia screening in RA was poor and did not differ from the general population, despite a higher risk of cardiovascular diseases.
评估类风湿关节炎(RA)患者心血管疾病预防的血脂异常筛查指南的依从性与普通人群相比。
我们进行了一项基于人群的 RA 队列研究,该研究纳入了 1996 年至 2006 年间不列颠哥伦比亚省所有的现患病例,并随访至 2010 年,同时匹配了普通人群对照。使用行政数据,我们在排除了既往患有糖尿病、冠心病或血脂异常的个体后,测量了符合普通人群指南(女性 ⩾50 岁和男性 ⩾40 岁每 5 年检测一次血脂)的情况。依从性的衡量标准为每 5 年有资格进行血脂检测的时期中进行一次或多次血脂检测的比例。通过卡方检验比较 RA 和对照组的依从率。使用广义估计方程模型调整年龄和性别后,估计 RA(与对照组相比)的依从率的比值比(95%置信区间)。还使用 Mann-Whitney U 检验计算并比较每位患者的平均依从率。
分析纳入了 5587 例 RA 患者和 5613 例对照,分别有 6993 和 7208 个 5 年的可评估期。在 RA 和对照组中,分别有 56.6%和 59.5%的可评估期进行了血脂检测[校正比值比(95%置信区间):0.97(0.90,1.06)]。与普通人群相比,RA 患者的筛查情况随时间推移而有所改善,但即使在 2003 年之后,情况仍不理想,为 65.8%。每位患者的平均(标准差)依从率分别为 RA 患者的 56.6(47.2)%和对照组的 59.5(46.6)%。家庭医生几乎开了所有的血脂检测单。
RA 患者血脂异常筛查的依从性与普通人群相比较差,且与普通人群相比差异无统计学意义,尽管心血管疾病风险较高。