Petracca Maria, Margoni Monica, Bommarito Giulia, Inglese Matilde
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Multiple Sclerosis Centre, Department of Neurosciences DNS, University Hospital, University of Padua, Padua, Italy.
Neurol Ther. 2018 Dec;7(2):265-285. doi: 10.1007/s40120-018-0103-2. Epub 2018 Jun 28.
Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1) provide an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.
用于监测进展型多发性硬化症（PMS）疾病进展的影像学标志物稀缺，这限制了在临床试验中监测疾病演变和测试有效治疗方法的可能性。具有对短期组织变化敏感度增加以及对PMS特征性结构异常特异性增加的指标优势的先进成像技术，最近已应用于PMS的临床试验中。在本综述中，我们（1）概述PMS的病理特征，（2）总结在PMS中应用传统和先进磁共振成像技术进行的研究和临床试验结果，以及（3）讨论使用成像技术监测PMS的最新进展和未来前景。
