Wang Yue, Zhang Ye, Lv Bingjian, Feng Ye
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
J Obstet Gynaecol Res. 2018 Aug;44(8):1492-1497. doi: 10.1111/jog.13692. Epub 2018 Jun 28.
Angiomyofibroblastoma (AMF) represents a rare, benign mesenchymal tumor with a predilection for the vulvovaginal region, which may be misdiagnosed as aggressive angiomyxoma (AAM). Herein, we report a case of a 20-year-old nulliparous Chinese woman with a unique pedunculated and polypoidal mass, which had been developing within the previous 6 months in the left labium majus, exhibiting the AAM clinical impression but diagnosed as AMF. The mass measured 18 × 10 × 6 cm, and contained diffuse ulcerated areas and purulent discharge. A complete excision of the mass was performed. There was no subsequent evidence of recurrence, according to a 13-month follow-up. As a rare benign vulvovaginal tumor, AMF can present on patients of an early reproductive age with rapidly growing, polypoidal pattern. The whole exon sequencing analysis revealed the genomic alterations, which may contribute to the occurrence of AMF.
血管肌纤维母细胞瘤（AMF）是一种罕见的良性间叶组织肿瘤，好发于外阴阴道区域，可能被误诊为侵袭性血管黏液瘤（AAM）。在此，我们报告一例20岁未生育的中国女性病例，其左大阴唇有一个独特的带蒂息肉样肿物，在过去6个月内逐渐增大，临床表现似AAM，但诊断为AMF。肿物大小为18×10×6cm，包含弥漫性溃疡区域及脓性分泌物。对肿物进行了完整切除。根据13个月的随访，未见复发迹象。作为一种罕见的良性外阴阴道肿瘤，AMF可出现在育龄早期患者中，表现为快速生长的息肉样形态。全外显子测序分析揭示了可能与AMF发生相关的基因组改变。
