Department of Materials Engineering, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.
Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8655 , Japan.
Langmuir. 2019 Feb 5;35(5):1954-1963. doi: 10.1021/acs.langmuir.8b01494. Epub 2018 Jul 11.
Recently, traditional strategies for manipulating orthopedic bearing substrates have attempted to improve their wear resistance by adjusting polyethylene substrate through cross-linking and antioxidant blending. However, further research is required on the substrate, as well as the surface focused on the structure and role of articular cartilage. We therefore develop an orthopedic bearing surface comprising a nanometer-scale hydrated gel-like layer by grafting highly hydrophilic poly(2-methacryloyloxyethyl phosphorylcholine), with the aim of mimicking the lubrication mechanism of articular cartilage, and investigate its surface characteristics, bulk characteristics, and behavior under load bearing conditions upon accelerated aging. Neither the hydrophilicity nor lubricity of the gel-like surface was influenced by accelerated aging; instead, high stability was revealed, even under strong oxidation conditions. The characteristics of the hydrated gel-like surface potentiated the wear resistance of the cross-linked polyethylene liner, irrespective of accelerated aging. These results suggest that the hydrated gel-like surface enhances the longevity of cross-linked polyethylene bearings even under load-bearing conditions. Furthermore, the inflection point on the time series of wear can be a suitable indicator of the durability of the life-long protectant. In conclusion, the hydrated gel-like surface can positively increase orthopedic implant durability.
最近，传统的骨科轴承衬底处理策略试图通过交联和抗氧化剂共混来调整聚乙烯衬底，以提高其耐磨性。然而，还需要进一步研究衬底，以及表面结构和关节软骨的作用。因此，我们通过接枝高亲水性聚（2-甲基丙烯酰氧乙基磷酸胆碱）开发了一种由纳米级水合凝胶层组成的骨科轴承表面，旨在模拟关节软骨的润滑机制，并研究其表面特性、体相特性以及在加速老化条件下的承载性能。水合凝胶表面的亲水性和润滑性都不受加速老化的影响，反而表现出很高的稳定性，即使在强氧化条件下也是如此。水合凝胶表面的特性增强了交联聚乙烯衬垫的耐磨性，而与加速老化无关。这些结果表明，即使在承载条件下，水合凝胶表面也能提高交联聚乙烯轴承的使用寿命。此外，磨损时间序列上的拐点可以作为长期保护剂耐用性的合适指标。总之，水合凝胶表面可以积极地提高骨科植入物的耐久性。
