Baggerman Jacob, Smulders Maarten M J, Zuilhof Han
Laboratory of Organic Chemistry , Wageningen University , Stippeneng 4 , 6708 WE Wageningen , The Netherlands.
School of Pharmaceutical Sciences and Technology , Tianjin University , 92 Weijin Road , Tianjin 300350 , People's Republic of China.
Langmuir. 2019 Feb 5;35(5):1072-1084. doi: 10.1021/acs.langmuir.8b03360. Epub 2019 Jan 8.
This Feature Article focuses on recent advances in the bioconjugation of surface-bound zwitterionic polymers for biospecific antifouling surfaces. Various approaches for the functionalization of antifouling zwitterionic polymers are systematically investigated, such as chain-end and side-chain functionalization. Side-chain functionalization methods can be further classified as those that are achieved through homopolymerization of custom-synthesized zwitterionic monomers equipped with reactive groups, or those that are achieved via synthesis of random or block copolymers combining different monomers with antifouling functionality and others with reactive groups. Several of the pros and cons of these approaches are outlined and discussed. Finally, some perspective and future directions of research are presented toward long-term stable, generically repelling surfaces that strongly and specifically adhere to a single component in a complex mixture.
这篇专题文章聚焦于用于生物特异性防污表面的表面结合两性离子聚合物生物共轭的最新进展。系统研究了防污两性离子聚合物功能化的各种方法，如链端和侧链功能化。侧链功能化方法可进一步分为通过配备反应性基团的定制合成两性离子单体的均聚实现的方法，或通过合成将具有防污功能的不同单体与具有反应性基团的其他单体结合的无规或嵌段共聚物实现的方法。概述并讨论了这些方法的若干优缺点。最后，针对长期稳定、能普遍排斥且能强烈且特异性地粘附于复杂混合物中单一成分的表面，提出了一些研究展望和未来方向。
