Department of Internal Medicine, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Spain.
Department of Internal Medicine, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Spain; CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBEROBN) Instituto de Salud Carlos III (ISCIII), Spain.
Clin Nutr. 2019 Jun;38(3):1036-1044. doi: 10.1016/j.clnu.2018.06.001. Epub 2018 Jun 8.
BACKGROUND & AIMS: There is compelling evidence showing that moderate alcohol consumption reduces cardiovascular risk factors related to atherosclerosis. The aim of this study was to evaluate the effects of aged white wine (AWW) and gin on circulating endothelial progenitor cells (EPC) and the expression of cell adhesion molecules, inflammatory cytokines and chemokines related to atherosclerosis in high cardiovascular risk subjects.
This was an open, randomized, controlled, crossover study in 38 high-risk male volunteers between 55 and 80 years of age randomized to receive 30 g of ethanol/day as AWW or gin during 3 weeks. We used the paired two-tailed t-test to compare differences in outcome variables in response to each intervention. Carryover effects for the two periods were evaluated comparing the outcome variables before the AWW and gin interventions.
Compared to gin, AWW intake was associated with a significant 39.6% increase in EPCs. Expression of CD31 and CD40 in T-lymphocytes and of CCR2 and CD36 in monocytes also decreased significantly after AWW intake. In addition, compared to gin, AWW was associated with a significant decrease of plasma pro-inflammatory biomarkers interleukin-8 and interleukin-18 and vascular and intercellular adhesion molecules-1. Lfa-1, Mac-1, VLA4, CD40 and CD31 expression in monocytes and interferon gamma (IFN-γ) concentrations significantly decreased after intake of both alcoholic beverages.
AWW shows a greater ability to repair and maintain endothelial integrity compared to gin. This effect is probably due to grape-derived minor components in AWW, which are absent in gin.
有充分证据表明，适量饮酒可降低与动脉粥样硬化相关的心血管危险因素。本研究旨在评估陈酿白葡萄酒（AWW）和金酒对高心血管风险人群循环内皮祖细胞（EPC）及与动脉粥样硬化相关的细胞黏附分子、炎症细胞因子和趋化因子表达的影响。
这是一项纳入 38 名年龄在 55 岁至 80 岁之间的高风险男性志愿者的开放、随机、对照、交叉研究，他们被随机分为 3 组，分别接受 3 周的 30g/d 乙醇作为 AWW 或金酒。我们使用配对双尾 t 检验比较两种干预措施下的结局变量差异。通过比较 AWW 和金酒干预前的结局变量，评估两种时期的交叉影响。
与金酒相比，AWW 摄入可使 EPC 增加 39.6%。T 淋巴细胞上的 CD31 和 CD40 以及单核细胞上的 CCR2 和 CD36 的表达也显著降低。此外，与金酒相比，AWW 与血浆促炎生物标志物白细胞介素-8 和白细胞介素-18 以及血管和细胞间黏附分子-1 的显著降低有关。与金酒相比，两种含酒精饮料摄入后，单核细胞上的 Lfa-1、Mac-1、VLA4、CD40 和 CD31 表达以及干扰素γ（IFN-γ）浓度均显著降低。
与金酒相比，AWW 具有更强的修复和维持内皮完整性的能力。这种作用可能归因于 AWW 中来源于葡萄的微量成分，而金酒中则不存在这些成分。
