Xingzhi College, Zhejiang Normal University, Lanxi, China.
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Medicine (Baltimore). 2024 Jun 7;103(23):e38229. doi: 10.1097/MD.0000000000038229.
Moderate red wine (RW) consumption is associated with a low risk of cardiovascular disease (CVD). However, few studies have evaluated the effects of RW and white wine (WW) on inflammatory markers related to atherosclerosis in healthy individuals and high-risk subjects for CVD. This study aimed to assess the effect of RW on inflammatory markers in healthy individuals and high-risk subjects for CVD compared with moderate alcohol consumption.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA) was followed in this study. The PubMed, Embase, Cochrane, Web of Science, SinoMed, EbscoHost, and ScienceDirect databases were searched. The risk of bias and quality of the included trials were assessed using the Cochrane Handbook. The main results are summarized in Stata 12.
Twelve studies were included in the meta-analysis. The results demonstrated that RW significantly decreased circulating intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-alpha (TNF-α), lymphocyte function-associated antigen-1, and Sialyl-Lewis X expression on the surface of monocytes in healthy subjects, but not in patients with CVD. Additionally, RW significantly decreased Sialyl-Lewis X but increased clusters of differentiation 40 (CD40) expressed on the surface of T lymphocytes and significantly decreased C-C chemokine receptor type 2 (CCR2) and very late activation antigen 4 (VLA-4) expressed on the surface of monocytes. Interestingly, subgroup analysis also found that RW significantly decreased circulating interleukin-6 (IL-6) in Spain but not in other countries, and significantly increased αMβ2 (Mac-1) in the group that had an intervention duration of less than 3 weeks.
Moderate consumption of RW is more effective than WW in alleviating atherosclerosis-related inflammatory markers in healthy people rather than high-risk subjects for CVD, but this needs to be further confirmed by studies with larger sample sizes.
适量饮用红葡萄酒（RW）与心血管疾病（CVD）风险降低有关。然而，很少有研究评估 RW 和白葡萄酒（WW）对健康人群和 CVD 高危人群与动脉粥样硬化相关的炎症标志物的影响。本研究旨在评估与中等量饮酒相比，RW 对健康人群和 CVD 高危人群炎症标志物的影响。
本研究遵循系统评价和荟萃分析的首选报告项目 2020（PRISMA）。检索了 PubMed、Embase、Cochrane、Web of Science、SinoMed、EbscoHost 和 ScienceDirect 数据库。使用 Cochrane 手册评估纳入试验的偏倚风险和质量。主要结果汇总在 Stata 12 中。
纳入了 12 项荟萃分析研究。结果表明，RW 可显著降低健康受试者循环细胞间黏附分子-1、血管细胞黏附分子-1（VCAM-1）、肿瘤坏死因子-α（TNF-α）、淋巴细胞功能相关抗原-1 和单核细胞表面唾液酸化路易斯 X 表达，但对 CVD 患者无影响。此外，RW 可显著降低 T 淋巴细胞表面 CD40 表达，但增加 Sialyl-Lewis X 表达，显著降低单核细胞表面 C-C 趋化因子受体 2（CCR2）和非常晚期激活抗原 4（VLA-4）表达。有趣的是，亚组分析还发现，RW 可显著降低西班牙人群的循环白细胞介素-6（IL-6），但在其他国家没有影响，并且在干预持续时间少于 3 周的组中显著增加αMβ2（Mac-1）表达。
与 WW 相比，适量饮用 RW 更能缓解健康人群而非 CVD 高危人群与动脉粥样硬化相关的炎症标志物，但这需要更大样本量的研究进一步证实。
