Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de Recherche "Résistance aux antibiotiques" LR99ES09, 1007, Tunis, Tunisie; Hôpital Charles Nicolle, Laboratoire de microbiologie, Tunis, Tunisie.
Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de Recherche "Résistance aux antibiotiques" LR99ES09, 1007, Tunis, Tunisie.
Int J Antimicrob Agents. 2018 Dec;52(6):906-909. doi: 10.1016/j.ijantimicag.2018.06.009. Epub 2018 Jun 26.
Emergence of the New Delhi metallo-β-lactamase (NDM-1), an Ambler class B metallo-β-lactamase able to hydrolyse all β-lactams except monobactams, constitutes a critical and increasingly important medical issue. The acquisition of bla is of particular concern for Proteus mirabilis, which is intrinsically resistant to tetracycline, tigecycline and colistin, as this will make clinical treatment extremely difficult. To the authors' knowledge, this is the first report of the bla gene in an extensively-drug-resistant P. mirabilis clinical isolate carrying plasmid-mediated resistance to carbapenems (bla), cephalosporins (bla), aminoglycosides (aph3 VIa and aph3 Ia) and fluoroquinolones (qnrA6).
新德里金属β-内酰胺酶（NDM-1）的出现是一个严重且日益重要的医学问题，这种 Ambler 分类 B 型金属β-内酰胺酶能够水解除单环β-内酰胺类抗生素以外的所有β-内酰胺类抗生素。对于固有耐四环素、替加环素和黏菌素的奇异变形杆菌来说，获得 bla 基因尤其令人担忧，因为这将使临床治疗变得极其困难。据作者所知，这是 bla 基因首次在一株广泛耐药的奇异变形杆菌临床分离株中被发现，该分离株对碳青霉烯类（bla）、头孢菌素类（bla）、氨基糖苷类（aph3 VIa 和 aph3 Ia）和氟喹诺酮类（qnrA6）具有质粒介导的耐药性。
