Luo Jia, Wang Xing Li, Sun Zhi Chao, Wu Di, Zhang Wei, Wang Zheng Jia
Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
Yi Chuan. 2018 Jun 20;40(6):467-477. doi: 10.16288/j.yczz.18-009.
Circular RNAs (circRNAs) are covalently closed, conserved single-stranded transcripts that are produced from precursor mRNA (pre-mRNA) back-splicing. They could function as microRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and linear mRNAs. Next-generation RNA sequencing (RNA-seq) has recently shown that the expression of circRNAs is widespread in plants. circRNAs participate in multiple biological processes such as floral development, fruit ripening, and biotic and abiotic stress responses by cell type-specific and tissue-specific expression patterns, indicating that they may play an important role in plant development. In this review, we summarize the current knowledge of plant circRNAs in recent years, including the biogenesis, detection, databases, expression pattern, and potential functions in comparison with animal results to provide new insights for functional research interests of circRNAs in the future.
环状RNA（circRNAs）是由前体mRNA（pre-mRNA）反向剪接产生的共价闭合、保守的单链转录本。它们可以作为微小RNA海绵发挥作用，干扰剪接并与蛋白质结合，从而调节亲本基因和线性mRNA的表达。新一代RNA测序（RNA-seq）最近表明，circRNAs在植物中广泛表达。circRNAs通过细胞类型特异性和组织特异性表达模式参与多种生物学过程，如花卉发育、果实成熟以及生物和非生物胁迫反应，这表明它们可能在植物发育中发挥重要作用。在本综述中，我们总结了近年来关于植物circRNAs的现有知识，包括其生物合成、检测、数据库、表达模式以及与动物研究结果相比的潜在功能，以便为未来circRNAs的功能研究提供新的见解。
