Li Quan-Feng, Zhang Yu-Chan, Chen Yue-Qin, Yu Yang
Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, 510275, PR China.
Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, 510275, PR China.
Biochem Biophys Res Commun. 2017 Jun 24;488(2):382-386. doi: 10.1016/j.bbrc.2017.05.061. Epub 2017 May 10.
As a novel class of endogenous non-coding RNAs, circular RNAs (circRNAs) have become a new research hotspot in recent years. The wide distribution of circRNAs in different plant species has been proven. Furthermore, circRNAs show significant tissue-specific expression patterns in plant development and are responsive to a variety of biotic and abiotic stresses, indicating that circRNAs might have important biological functions in plant development. Here, we summarize the current knowledge of plant circRNAs in recent years and discuss views and perspectives on the possible regulatory roles of plant circRNAs, including the function of miRNA sponges, regulating the expression of their parental genes or linear mRNAs, translating into peptides or proteins and responses to different stresses. These advances have sculpted a framework of plant circRNAs and provide new insights for functional RNA regulation research in the future.
作为一类新型的内源性非编码RNA，环状RNA（circRNAs）近年来已成为一个新的研究热点。circRNAs在不同植物物种中的广泛分布已得到证实。此外，circRNAs在植物发育过程中表现出显著的组织特异性表达模式，并对多种生物和非生物胁迫作出响应，这表明circRNAs可能在植物发育中具有重要的生物学功能。在此，我们总结了近年来关于植物circRNAs的现有知识，并讨论了关于植物circRNAs可能的调控作用的观点和展望，包括作为miRNA海绵的功能、调控其亲本基因或线性mRNA的表达、翻译成肽或蛋白质以及对不同胁迫的响应。这些进展构建了植物circRNAs的框架，并为未来的功能性RNA调控研究提供了新的见解。
