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伊朗西南部阿瓦兹市环境空气中多环芳烃暴露与癌症风险的关系。

Association between cancer risk and polycyclic aromatic hydrocarbons' exposure in the ambient air of Ahvaz, southwest of Iran.

机构信息

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Asadabad School of Medical Sciences, Asadabad, Iran.

出版信息

Int J Biometeorol. 2018 Aug;62(8):1461-1470. doi: 10.1007/s00484-018-1543-1. Epub 2018 Jun 29.

DOI:10.1007/s00484-018-1543-1
PMID:29959528
Abstract

Nowadays, a large number of health endpoints such as disease rates, treatment costs, and death, by air pollutants, have been a serious health problem for humans. One of the most hazardous air pollutants, which is highly dangerous for human health, is polycyclic aromatic hydrocarbons (PAHs). The existence of the emission of industries' pollutants and seasonal variations are the primary agents affecting PAHs' concentration. The purposes of this study were to calculate the cancer risk and measure PAHs' exposure in the ambient air of Ahvaz, southwest of Iran, during 2017. Three distinct areas ((S1) industrial, (S2) high traffic, and (S3) residential) of Ahvaz metropolitan were selected. Omni sampler equipped with polytetrafluoroethylene (PTFE) filters were used for active sampling of PAHs. To detect the level of PAHs, gas chromatography with mass spectrometry (GC/MS) was used. Incremental lifetime cancer risk (ILCR) and lifetime average daily dose (LADD) were used to estimate the health risk caused by PAHs. The results showed that the residential and industrial areas had the lowest and highest level of PAHs. Moreover, the average levels of PAHs in industrial, high traffic, and residential areas were 8.44 ± 3.37, 7.11 ± 2.64, and 5.52 ± 1.63 ng m, respectively. Furthermore, ILCR in autumn and winter was higher than EPA standard, 0.06307 and 0.04718, respectively. In addition, ILCR in different areas was significantly higher than standard. Research findings imply that the levels of exposure to PAHs can increase ILCR and risk of health endpoint. The cancer risk attributed to PAHs should be further investigated from the perspective of the public health in metropolitans.

摘要

如今,大量健康终点,如疾病发生率、治疗成本和死亡率等,都受到空气污染物的影响,这已经成为人类面临的严重健康问题。其中,多环芳烃(PAHs)是最危险的空气污染物之一,对人类健康危害极大。工业污染物的排放和季节性变化是影响 PAHs 浓度的主要因素。本研究旨在计算伊朗西南部阿瓦士市环境空气中的癌症风险,并测量 PAHs 的暴露量。在阿瓦士大都市选择了三个不同的区域(S1)工业、(S2)高交通和(S3)住宅。使用带有聚四氟乙烯(PTFE)过滤器的 Omni 采样器进行 PAHs 的主动采样。为了检测 PAHs 的水平,使用气相色谱质谱联用仪(GC/MS)。增量终生癌症风险(ILCR)和终生平均日剂量(LADD)用于估计 PAHs 引起的健康风险。结果表明,住宅和工业区的 PAHs 水平最低和最高。此外,工业区、高交通区和住宅区的 PAHs 平均水平分别为 8.44±3.37、7.11±2.64 和 5.52±1.63ng/m。此外,秋季和冬季的 ILCR 高于 EPA 标准,分别为 0.06307 和 0.04718。此外,不同地区的 ILCR 明显高于标准。研究结果表明,PAHs 的暴露水平会增加 ILCR 和健康终点的风险。应从大都市公共卫生的角度进一步调查 PAHs 引起的癌症风险。

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