应激颗粒形成是宿主细胞针对柯萨奇病毒 B 感染的早期抗病毒机制之一。
Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection.
机构信息
Department of Microbiology, Harbin Medical University, Harbin, 150081, China.
Department of Cell Biology, Harbin Medical University, Harbin, 150081, China.
出版信息
Virol Sin. 2018 Aug;33(4):314-322. doi: 10.1007/s12250-018-0040-3. Epub 2018 Jun 29.
Abstract
Stress granules (SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B (CVB) infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3 (CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.
摘要
应激颗粒（SGs）是细胞翻译受阻时形成的细胞内颗粒，已有报道称其参与了多种病毒感染。我们之前的研究表明，SGs 参与了柯萨奇病毒 B（CVB）的感染过程，但 SGs 在 CVB 感染中的作用尚未被充分探索。在本研究中，我们发现 CVB 型 3（CVB3）可以在感染的早期诱导 SG 的形成。结果表明，在 CVB3 感染的早期阶段，由于 SG 的形成增加，CVB3 RNA 和蛋白的水平显著受到抑制，而当 SG 的形成被阻断时，病毒 RNA 和蛋白的合成则显著增加。我们的研究结果表明，SG 的形成是宿主细胞对抗 CVB 感染的早期抗病毒机制之一。
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