Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Viruses. 2023 Feb 6;15(2):449. doi: 10.3390/v15020449.
Viruses depend on host cellular resources to replicate. Interaction between viral and host proteins is essential for the pathogens to ward off immune responses as well as for virus propagation within the infected cells. While different viruses employ unique strategies to interact with diverse sets of host proteins, the multifunctional RNA-binding protein G3BP1 is one of the common targets for many viruses. G3BP1 controls several key cellular processes, including mRNA stability, translation, and immune responses. G3BP1 also serves as the central hub for the protein-protein and protein-RNA interactions within a class of biomolecular condensates called stress granules (SGs) during stress conditions, including viral infection. Increasing evidence suggests that viruses utilize distinct strategies to modulate G3BP1 function-either by degradation, sequestration, or redistribution-and control the viral life cycle positively and negatively. In this review, we summarize the pro-viral and anti-viral roles of G3BP1 during infection among different viral families.
病毒依赖宿主细胞资源进行复制。病毒和宿主蛋白之间的相互作用对于病原体逃避免疫反应以及在感染细胞内进行病毒传播至关重要。虽然不同的病毒采用独特的策略与不同的宿主蛋白相互作用，但多功能 RNA 结合蛋白 G3BP1 是许多病毒的常见靶标之一。G3BP1 控制着几种关键的细胞过程，包括 mRNA 稳定性、翻译和免疫反应。G3BP1 还作为一种中央枢纽，在应激条件下，包括病毒感染时，参与一类称为应激颗粒（SGs）的生物分子凝聚物中的蛋白质-蛋白质和蛋白质-RNA 相互作用。越来越多的证据表明，病毒利用不同的策略来调节 G3BP1 的功能，无论是通过降解、隔离还是重新分布，并积极和消极地控制病毒的生命周期。在这篇综述中，我们总结了不同病毒家族感染过程中 G3BP1 的促病毒和抗病毒作用。
