Ryan Matthew J, Perera Divaka
The Rayne Institute, St Thomas' Hospital, 4th Floor Lambeth Wing, Westminster Bridge Road, London, SE1 7EH, UK.
Cardiovascular Division, King's College London, London, UK.
Curr Heart Fail Rep. 2018 Aug;15(4):214-223. doi: 10.1007/s11897-018-0396-6.
Hibernation is an important and reversible cause of myocardial dysfunction in ischaemic heart failure.
Hibernation is an adaptive process that promotes myocyte survival over maintaining contractile function. It is innate to mammalian physiology, sharing features with physiological hibernation in other species. Advanced imaging methods have reasonable accuracy in identifying hibernating myocardium. Novel superior hybrid methods may provide diagnostic potential. New evidence supports the role of surgical revascularisation in ischaemic heart failure, but the role of viability tests in planning such procedures remains unclear. Research to date has exclusively involved patients with ambulatory heart failure: Investigating the role of hibernation in ADHF is a key avenue for the future. Whilst our understanding of hibernation pathophysiology has improved dramatically, the clinical utility of identifying and targeting hibernation remains unclear.
冬眠是缺血性心力衰竭中心肌功能障碍的一个重要且可逆的原因。
冬眠是一个适应性过程，其促进心肌细胞存活而非维持收缩功能。它是哺乳动物生理学所固有的，与其他物种的生理性冬眠具有共同特征。先进的成像方法在识别冬眠心肌方面具有合理的准确性。新型的高级混合方法可能具有诊断潜力。新证据支持外科血运重建在缺血性心力衰竭中的作用，但存活能力测试在规划此类手术中的作用仍不明确。迄今为止的研究仅涉及非卧床心力衰竭患者：研究冬眠在急性失代偿性心力衰竭中的作用是未来的一个关键方向。虽然我们对冬眠病理生理学的理解有了显著提高，但识别和针对冬眠的临床效用仍不明确。
