Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, School of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Chicago, Illinois.
Fertil Steril. 2018 Aug;110(3):523-533.e14. doi: 10.1016/j.fertnstert.2018.04.024. Epub 2018 Jun 28.
OBJECTIVE(S): To analyze whether first-degree relatives (FDR) of patients with polysystic ovary syndrome (PCOS) have an increased risk of insulin resistance and glucose intolerance.
Systematic review and meta-analysis.
None.
PATIENT(S): Parents and siblings of women with and without PCOS.
INTERVENTION(S): Search of PubMed database from 1960 to September 2017 with cross-checking of references of relevant articles in English.
MAIN OUTCOME MEASURE(S): Prevalence of type 2 diabetes mellitus (T2DM) and impaired glucose tolerance, and levels of fasting insulin, 2-hour insulin levels, and homeostatic model assessment insulin resistance (HOMA IR).
RESULT(S): Our search retrieved 4,796 articles of which 19 were included. The prevalence of T2DM was significantly increased in mothers and fathers of PCOS probands (rate ratio [RR] 2.43; 95% confidence interval [CI], 1.58-3.75, and RR 2.27; 95% CI, 1.25-4.12). Moreover, the fasting insulin (in mothers, fathers, and sisters) and HOMA IR (in mothers, fathers, and sisters) levels were statistically significantly higher in parents and siblings of PCOS patients. The sisters (RR 1.34; 95% CI, 0.59-3.03) and brothers (RR 1.51; 95% CI, 0.63-3.62) had a higher prevalence of T2DM than the control subjects, but the difference was not statistically significant.
CONCLUSION(S): Our meta-analysis provides quantitative evidence demonstrating clustering of T2DM and insulin resistance in the parents and siblings of PCOS probands.
PROSPERO 2016 CRD42016048551.
分析多囊卵巢综合征（PCOS）患者的一级亲属（FDR）是否存在胰岛素抵抗和葡萄糖耐量异常的风险增加。
系统评价和荟萃分析。
无。
患有和不患有 PCOS 的女性的父母和兄弟姐妹。
从 1960 年到 2017 年 9 月在 PubMed 数据库中进行搜索，并对英文相关文章的参考文献进行交叉核对。
2 型糖尿病（T2DM）和葡萄糖耐量异常的患病率，以及空腹胰岛素、2 小时胰岛素水平和稳态模型评估胰岛素抵抗（HOMA IR）的水平。
我们的搜索共检索到 4796 篇文章，其中 19 篇被纳入。PCOS 先证者的母亲和父亲中 T2DM 的患病率显著增加（比值比 [RR] 2.43；95%置信区间 [CI]，1.58-3.75，RR 2.27；95% CI，1.25-4.12）。此外，PCOS 患者的父母和兄弟姐妹的空腹胰岛素（母亲、父亲和姐妹）和 HOMA IR（母亲、父亲和姐妹）水平也存在统计学显著升高。与对照组相比，姐妹（RR 1.34；95% CI，0.59-3.03）和兄弟（RR 1.51；95% CI，0.63-3.62）的 T2DM 患病率更高，但差异无统计学意义。
我们的荟萃分析提供了定量证据，证明 PCOS 先证者的父母和兄弟姐妹中 T2DM 和胰岛素抵抗存在聚集现象。
PROSPERO 2016 CRD42016048551。
