Iurkov Iu A, Bakanov M I, Gerasimova Iu V
Vopr Med Khim. 1985 Jul-Aug;31(4):54-60.
Components of the cyclic nucleotide system--cAMP, cGMP, activities of adenylate cyclase (AC) and phosphodiesterase (PDase) were studied in brain, lung, adrenal gland, liver tissues, in blood plasma (cAMP, cGMP) and in leukocytes (AC and PDase) of guinea pigs at the periods of sensibilization and development of anaphylaxis. Dibutyryl cAMP was preadministered in a number of the animals in order to correct possible alterations in the system of cyclic nucleotides and to stimulate unspecific resistance of the organism. Distinct alterations were observed in the patterns studied after sensibilization of the animals, especially pronounced in anaphylactic shock. Preadministration of dibutyryl cAMP prevented development of anaphylactic shock in all the animals treated with the antigen. Even after repeated administration of the antigen the antigen. Even after repeated administration of the antigen the anaphylactic shock was observed only in 50% of these animals. The data obtained suggest that synthetic analogues of cAMP may be used for treatment of patients with allergic disorders.
在致敏期和过敏反应发展期，研究了豚鼠脑、肺、肾上腺、肝组织、血浆（cAMP、cGMP）和白细胞（腺苷酸环化酶（AC）和磷酸二酯酶（PDase））中环状核苷酸系统的组成成分——cAMP、cGMP、AC和PDase的活性。为了纠正环状核苷酸系统中可能出现的变化并刺激机体的非特异性抵抗力，给一些动物预先注射了二丁酰cAMP。在动物致敏后，所研究的各项指标出现了明显变化，在过敏性休克中尤为显著。预先注射二丁酰cAMP可防止所有接受抗原治疗的动物发生过敏性休克。即使再次注射抗原，这些动物中也只有50%出现过敏性休克。所得数据表明，cAMP的合成类似物可用于治疗过敏性疾病患者。
