Demidov S V, Kostromin A N, Kuĭbeda V V, Chernaia I V, Borovok M I
Ukr Biokhim Zh (1978). 1991 Jul-Aug;63(4):104-6.
It is established that the effect of thymus-derived species is connected with the cyclic nucleotide system. The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization. They show that sensibilization of the animal is bound up with a decrease of the cAMP/cGMP ratio. Anaphylaxis induces levelling of the cAMP/cGMP ratio up to the reference level. So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.
已经确定胸腺衍生物质的作用与环核苷酸系统有关。在过敏反应和致敏条件下，观察到胸腺衍生的免疫调节剂（胸腺素、胸腺生成素、维洛森）对环核苷酸分解代谢过程的作用。结果表明，动物的致敏与cAMP/cGMP比值的降低有关。过敏反应会使cAMP/cGMP比值趋于平稳，直至达到参考水平。因此，在致敏豚鼠的淋巴细胞中，由于胸腺生成素、胸腺素和维洛森的影响，环核苷酸分解代谢酶的活性增强，而在接受过敏反应治疗的动物的淋巴细胞中，该活性则有增加的趋势。
