Zhang Shijian, Yang Xi, Wang Lei, Zhang Chenping
Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, P.R. China.
Oncol Lett. 2018 Jul;16(1):679-686. doi: 10.3892/ol.2018.8716. Epub 2018 May 16.
Cancer stem cells (CSCs), which have a close connection with tumor microenvironment, play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory microenvironment is an essential component of tumor microenvironment. In the recent years, many studies have demonstrated that the inflammatory microenvironment induces the initiation of tumors, and contributes to the process of the progression of tumors, as well as metastasis. In this review, we summarize the relationship between CSCs and inflammatory components, such as inflammatory cytokines (IFNs, TNF, IL-6, IL-17) and inflammatory cells (myeloid-derived suppressor cells, tumor-associated macrophages). To illuminate the key factors that exert important actions in the tumor process would be important to improve the clinical outcome of the treatment for different types of cancer.
癌症干细胞（CSCs）与肿瘤微环境密切相关，在肿瘤发生、发展和转移中起关键作用。炎症微环境是肿瘤微环境的重要组成部分。近年来，许多研究表明，炎症微环境诱导肿瘤的起始，并促进肿瘤进展和转移过程。在本综述中，我们总结了癌症干细胞与炎症成分之间的关系，如炎症细胞因子（IFN、TNF、IL-6、IL-17）和炎症细胞（髓源性抑制细胞、肿瘤相关巨噬细胞）。阐明在肿瘤过程中发挥重要作用的关键因素对于改善不同类型癌症的治疗临床结果具有重要意义。
