Im Kyung Hoan, Choi Jaehyuk, Baek Seung-A, Lee Tae Soo
Division of Life Sciences, Incheon National University, Incheon, South Korea.
Mycobiology. 2018 Apr 26;46(2):159-167. doi: 10.1080/12298093.2018.1461316. eCollection 2018.
This study evaluated the and hypolipidemic effects of the medicinal mushroom . The methanol extract (ME) of the fruiting body of . was active against pancreatic lipase and cholesterol esterase with 99.14% and 67.23% inhibited activity at 1.0 mg/mL, respectively. It also inhibited 81.81% and 55.33% of α-glucosidase and α-amylase activities, respectively, at 2.0 mg/mL. Hyperlipidemia as induced by feeding rats with a high fat and cholesterol diet (HFC). HFC supplemented with a 5% fruiting body powder of . (HFC + PhP) significantly reduced plasma total cholesterol, low-density lipoprotein cholesterol, and triglycerides in rats compared with HFC. The reduced levels were comparable to rats fed the normal control diet (NC). The atherogenic index of HFC + PhP rats was significantly lower than that of the HFC rats. The excretion of fecal total lipid and cholesterol in the HFC + PhP rats was significantly higher than those in the NC and HFC rats. Histopathological examinations demonstrated scant deposition of lipids in the liver of rats fed HFC + PhP. The dietary supplementation with the fruiting body powder provided natural plasma lipid and glucose lowering effects in experimental rats without adverse effects on the plasma biochemical parameters and liver function related enzyme activities. Therefore, the hypolipidemic effects of may be due to the inhibitory effects on pancreatic lipase, cholesterol esterase, α-glucosidase, and α-amylase, and excretion of excess lipids and cholesterol in the feces.
本研究评估了药用蘑菇[蘑菇名称未给出]的降血脂和低脂血症作用。[蘑菇名称未给出]子实体的甲醇提取物（ME）对胰脂肪酶和胆固醇酯酶具有活性，在1.0毫克/毫升时，其抑制活性分别为99.14%和67.23%。在2.0毫克/毫升时，它还分别抑制了81.81%和55.33%的α-葡萄糖苷酶和α-淀粉酶活性。通过给大鼠喂食高脂肪和高胆固醇饮食（HFC）诱导高脂血症。补充5%[蘑菇名称未给出]子实体粉末的HFC（HFC+PhP）与HFC相比，显著降低了大鼠的血浆总胆固醇、低密度脂蛋白胆固醇和甘油三酯。降低的水平与喂食正常对照饮食（NC）的大鼠相当。HFC+PhP大鼠的动脉粥样硬化指数显著低于HFC大鼠。HFC+PhP大鼠粪便中总脂质和胆固醇的排泄量显著高于NC和HFC大鼠。组织病理学检查表明，喂食HFC+PhP的大鼠肝脏中脂质沉积较少。在实验大鼠中，饮食补充子实体粉末可自然降低血浆脂质和葡萄糖水平，且对血浆生化参数和肝功能相关酶活性无不良影响。因此，[蘑菇名称未给出]的降血脂作用可能归因于对胰脂肪酶、胆固醇酯酶、α-葡萄糖苷酶和α-淀粉酶的抑制作用，以及粪便中多余脂质和胆固醇的排泄。
