从直立百部块根中分离得到的两个新的聚酮化合物。
Two new polyketides from the roots of Stemona tuberosa.
机构信息
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
出版信息
Fitoterapia. 2018 Sep;129:150-153. doi: 10.1016/j.fitote.2018.06.025. Epub 2018 Jun 28.
Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones. The plausible biosynthetic pathways for 1 and 2 were also proposed. Anti-inflammatory assay confirmed that the two compounds showed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor.
从直立百部（Stemona tuberosa）的根部分离得到两种具有新型骨架的聚酮化合物，分别为 stemonones A（1）和 B（2）。通过全面的光谱分析和实验电子圆二色谱（ECD）光谱与计算光谱的比较，充分确定了它们的绝对结构。还提出了 1 和 2 的可能生物合成途径。抗炎试验证实，这两种化合物对血小板激活因子诱导的大鼠多形核白细胞（PMN）β-葡萄糖醛酸酶释放具有中等抑制作用。
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