双微体是染色体吗？
Are double minutes chromosomes?
作者信息
Barker P E, Hsu T C
机构信息
Department of Biology, University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston 77030.
出版信息
Exp Cell Res. 1978 May;113(2):456-8. doi: 10.1016/0014-4827(78)90391-9.
Double minutes of a human breast cancer cell line revealed no centromeres by Cd banding. They cluster at the periphery of metaphase plates, usually encased in a matrix material. They move in anaphase passively with the chromosomes by attaching to the sides or ends of the chromosomes. The two "sister minutes" move to the same pole without separation. Such anomalous mitotic behavior suggests that double minutes are not chromosomes.
通过Cd分带显示，一种人类乳腺癌细胞系的双微体没有着丝粒。它们聚集在中期板的周边，通常被包裹在一种基质物质中。在后期，它们通过附着在染色体的侧面或末端，与染色体一起被动移动。两个“姐妹双微体”会移向同一极而不分离。这种异常的有丝分裂行为表明双微体不是染色体。
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