Akmal Jan Sher, Salmi Mika, Mäkitie Antti, Björkstrand Roy, Partanen Jouni
Department of Mechanical Engineering, Aalto University, 02150 Espoo, Finland.
Department of Otorhinolaryngology⁻Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
J Funct Biomater. 2018 Jun 29;9(3):41. doi: 10.3390/jfb9030041.
The purpose of this study is to demonstrate the ability of additive manufacturing, also known as 3D printing, to produce effective drug delivery devices and implants that are both identifiable, as well as traceable. Drug delivery devices can potentially be used for drug release in the direct vicinity of target tissues or the selected medication route in a patient-specific manner as required. The identification and traceability of additively manufactured implants can be administered through radiofrequency identification systems. The focus of this study is to explore how embedded medication and sensors can be added in different additive manufacturing processes. The concept is extended to biomaterials with the help of the literature. As a result of this study, a patient-specific drug delivery device can be custom-designed and additively manufactured in the form of an implant that can identify, trace, and dispense a drug to the vicinity of a selected target tissue as a patient-specific function of time for bodily treatment and restoration.
本研究的目的是证明增材制造(也称为3D打印)生产有效药物递送装置和植入物的能力,这些装置和植入物既具有可识别性,又具有可追溯性。药物递送装置有可能根据需要以患者特定的方式用于在靶组织附近直接释放药物或选择给药途径。增材制造植入物的识别和可追溯性可通过射频识别系统来实现。本研究的重点是探索如何在不同的增材制造过程中添加嵌入式药物和传感器。借助文献将这一概念扩展到生物材料。作为本研究的成果,一种针对患者定制的药物递送装置可以被定制设计并以植入物的形式进行增材制造,该植入物能够作为针对身体治疗和恢复的特定于患者时间函数,识别、追踪并将药物分配到选定靶组织附近。