1 Department of Tissue Engineering, Center of 3D Printing and Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), Shenyang, Liaoning Province, P.R. China.
2 Department of Mechanical Engineering, Center of Organ Manufacturing, Tsinghua University, Beijing, P.R. China.
Cell Transplant. 2019 Jan;28(1):5-17. doi: 10.1177/0963689718809918. Epub 2018 Nov 26.
Bioartificial organ manufacturing technologies are a series of enabling techniques that can be used to produce human organs based on bionic principles. During the last ten years, significant progress has been achieved in the development of various organ manufacturing technologies. According to the degree of automation, organ manufacturing technologies can be divided into three main groups: (1) fully automated; (2) semi-automated; (3) handworked (or handmade); each has the advantages and disadvantages for bioartificial organ manufacturing. One of the most promising bioartificial organ manufacturing technologies is to use combined multi-nozzle three-dimensional printing techniques to automatically assemble personal cells along with other biomaterials to build exclusive organ substitutes for defective/failed human organs. This is the first time that advanced bioartificial organ manufacturing technologies have been reviewed. These technologies hold the promise to greatly improve the quality of health and average lifespan of human beings in the near future.
生物人工器官制造技术是一系列能够基于仿生原理制造人体器官的使能技术。在过去的十年中，各种器官制造技术取得了重大进展。根据自动化程度的不同，器官制造技术可分为三大类：（1）全自动；（2）半自动；（3）手工（或手工制作）；每种技术在生物人工器官制造方面都有其优缺点。最有前途的生物人工器官制造技术之一是使用组合多喷嘴三维打印技术自动组装个人细胞以及其他生物材料，为有缺陷/失效的人体器官构建独特的器官替代品。这是首次对先进的生物人工器官制造技术进行综述。这些技术有望在不久的将来极大地提高人类的健康质量和平均寿命。
