Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Rhode Island Hospital, 593 Eddy Street, POB Suite 224, Providence, RI 02903, USA.
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Rhode Island Hospital, 593 Eddy Street, POB Suite 224, Providence, RI 02903, USA.
Heart Fail Clin. 2018 Jul;14(3):339-351. doi: 10.1016/j.hfc.2018.02.009.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a distinct type of pulmonary hypertensive disease, characterized by incomplete or abnormal resolution of acute pulmonary embolism such that residual emboli become organized and fibrotic. CTEPH can occur in patients without a prior history of venous thromboembolism, and is diagnosed based on precapillary pulmonary hypertension on right heart catheterization with evidence of chronic emboli on ventilation/perfusion scan, chest imaging, or pulmonary angiogram. Pulmonary endarterectomy (PEA) is often curative, and results in improved survival. In patients for whom PEA is not feasible, medical therapy has been effective in improving hemodynamics and functional capacity.
慢性血栓栓塞性肺动脉高压（CTEPH）是一种特殊类型的肺动脉高压疾病，其特征为急性肺栓塞未能完全或异常溶解，残留栓子机化和纤维化。CTEPH 可发生于无静脉血栓栓塞症病史的患者，诊断依据为右心导管检查发现毛细血管前肺动脉高压，同时通气/灌注扫描、胸部影像学或肺动脉造影提示存在慢性栓塞。肺动脉内膜切除术（PEA）通常可根治，并改善生存。对于不适合行 PEA 的患者，药物治疗可有效改善血液动力学和功能能力。
