阿法骨化醇作为低度非霍奇金淋巴瘤生长的调节剂。
Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas.
作者信息
Cunningham D, Gilchrist N L, Cowan R A, Forrest G J, McArdle C S, Soukop M
出版信息
Br Med J (Clin Res Ed). 1985 Oct 26;291(6503):1153-5. doi: 10.1136/bmj.291.6503.1153.
Ten patients with low grade non-Hodgkin's lymphoma (seven follicular small cleaved and three small lymphocytic) were treated with 1 microgram oral alfacalcidol (1 alpha-hydroxycholecalciferol) daily. Of the seven patients with lymphomas of follicular small cleaved subtype, one achieved complete and three partial remission, whereas none of three patients with small lymphocytic lymphomas responded. In seven of the 10 patients, 1,25(OH)2D3 receptors were measured in tissue from lymph nodes, and a positive correlation between the presence and amount of receptor and response to alfacalcidol was found. These preliminary data suggest that alfacalcidol has appreciable antitumour activity in low grade non-Hodgkin's lymphomas.
十名低度非霍奇金淋巴瘤患者（七名滤泡性小裂细胞型和三名小淋巴细胞型）接受每日1微克口服阿法骨化醇（1α-羟基胆钙化醇）治疗。在七名滤泡性小裂细胞亚型淋巴瘤患者中，一名达到完全缓解，三名达到部分缓解，而三名小淋巴细胞淋巴瘤患者均无反应。在10名患者中的7名患者中，对淋巴结组织进行了1,25(OH)2D3受体检测，发现受体的存在和数量与对阿法骨化醇的反应之间存在正相关。这些初步数据表明，阿法骨化醇在低度非霍奇金淋巴瘤中具有明显的抗肿瘤活性。
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