田口法优化 FeO@壳聚糖/黄蓍胶纳米复合材料的合成及其作为药物传递系统的研究。
Taguchi method optimization for synthesis of FeO @chitosan/Tragacanth Gum nanocomposite as a drug delivery system.
机构信息
Department of Chemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Department of Chemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
出版信息
Carbohydr Polym. 2019 Oct 15;222:114982. doi: 10.1016/j.carbpol.2019.114982. Epub 2019 Jun 7.
Polysaccharides as natural hydrogels provide a promising strategy to prepare stimuli responsive drug carriers in pharmaceutical industries. In this work, FeO magnetic nanoparticles (MNPs) functionalized with (3-amino propyl) triethoxy silane (APTES) and coated by Chitosan (CS) and Tragacanth Gum (TG) to encapsulate curcumin. The synthesized nanocomposite was characterized using FT-IR, FE-SEM, EDX and XRD analysis. Taguchi Method (L9) with 3 levels and 4 variables was used to optimize the effect of concentration of FeO@APTES, TG: CS ratio, nanocomposite weight, and curcumin weight on the drug loading. The release behaviour of curcumin was further studied in two different pH 7.4 and 3.4 and at temperatures 37 °C and 40 °C. The nanocomposite showed a higher swelling ratio at pH 3.4 and temperature 40 °C with good pH and thermosensitive in vitro drug release profiles. The results indicate that the nanocomposite has a good potential for delivery of chemotherapeutic drugs.
多糖作为天然水凝胶为制药工业中制备刺激响应性药物载体提供了一种很有前途的策略。在这项工作中，用（3-氨丙基）三乙氧基硅烷（APTES）功能化的 FeO 磁性纳米粒子（MNPs），并涂覆壳聚糖（CS）和刺云实胶（TG）以包封姜黄素。通过 FT-IR、FE-SEM、EDX 和 XRD 分析对合成的纳米复合材料进行了表征。采用 Taguchi 方法（L9），3 个水平和 4 个变量，优化了 FeO@APTES 浓度、TG:CS 比、纳米复合材料重量和姜黄素重量对药物负载的影响。进一步研究了在两种不同 pH 值 7.4 和 3.4 以及温度 37°C 和 40°C 下姜黄素的释放行为。纳米复合材料在 pH 3.4 和温度 40°C 下具有更高的溶胀率，具有良好的 pH 和温度敏感性体外药物释放曲线。结果表明，该纳米复合材料在化疗药物的传递方面具有良好的应用潜力。
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