Giacchero A, Aste H, Baracchini P, Conio M, Fulcheri E, Lapertosa G, Tanzi R
Cancer. 1985 Dec 1;56(11):2723-6. doi: 10.1002/1097-0142(19851201)56:11<2723::aid-cncr2820561137>3.0.co;2-n.
Nine cases of signet-ring carcinoma have been observed from among 800 consecutive histologic cases diagnosed as adenocarcinoma of the colon during a period of 10 years (0.9%). This group of nine patients (Group A) has been matched for sex, age, and stage with a group of 45 patients affected by ordinary carcinoma of the colon (Group B). Clinical and histologic parameters, including symptoms, primary tumor site, free interval from primary surgery, histochemical investigation of intracytoplasmic mucins, and survival, were evaluated. The results of this investigation showed no clinical differences between signet-ring carcinoma and ordinary carcinoma, and no statistically significant results were observed regarding the frequency of local recurrence and actuarial survival.
在10年期间连续诊断的800例结肠腺癌组织学病例中，观察到9例印戒细胞癌（0.9%）。将这9例患者（A组）与45例患普通结肠癌的患者（B组）在性别、年龄和分期方面进行匹配。对临床和组织学参数进行了评估，包括症状、原发肿瘤部位、初次手术后的无瘤间期、细胞质黏液的组织化学研究以及生存率。该研究结果显示，印戒细胞癌与普通癌之间无临床差异，在局部复发频率和精算生存率方面也未观察到统计学上的显著结果。
