Zhou Tingting, Li Dan, Chen Qianming, Hua Hong, Li Chunlei
Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
Department of Oral Medicine, West China School of Stomatology, SiChuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2018 Jun 18;9:330. doi: 10.3389/fendo.2018.00330. eCollection 2018.
A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.
This study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.
192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case-control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto's thyroiditis (HT), hypothyroidism, and thyroid nodule].
The prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87-5.33) for OLP, 2.09 (1.18-3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30-4.09) for OLP.
Our study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.
近年来，口腔扁平苔藓（OLP）与甲状腺疾病之间的潜在关系受到了关注。
本研究旨在评估中国患者中OLP与甲状腺疾病之间的相关性。
本病例对照研究招募了192例OLP患者、123例口腔苔藓样病变（OLL）患者和162名对照。所有参与者均接受甲状腺功能筛查并进行超声检查。三组患者的性别和年龄相匹配。分析受试者中甲状腺疾病的患病率。采用逻辑回归分析，评估OLP、OLL与不同类型甲状腺疾病[桥本甲状腺炎（HT）、甲状腺功能减退和甲状腺结节]之间关联的比值比（OR）及95%置信区间。
OLP组（72.4%）和OLL组（68.3%）甲状腺疾病的患病率高于对照组（49.4%），差异有统计学意义。OLP患者患HT的OR为3.16（1.87 - 5.33），OLL患者为2.09（1.18 - 3.70），而OLP患者患甲状腺结节的OR为2.31（1.30 - 4.09）。
我们的研究表明，在中国人群中OLP/OLL与HT和甲状腺结节之间存在密切关系。这种关联背后的潜在机制值得进一步研究。
