桥本甲状腺炎患者血清白细胞介素-17水平升高。
Increased Levels of Serum Interleukin-17 in Patients with Hashimoto's Thyroiditis.
作者信息
Esfahanian Fatemeh, Ghelich Roghayeh, Rashidian Hoda, Jadali Zohreh
机构信息
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Endocrinology, Imam Khomeini General Hospital, Tehran, Iran.
出版信息
Indian J Endocrinol Metab. 2017 Jul-Aug;21(4):551-554. doi: 10.4103/ijem.IJEM_412_16.
BACKGROUND
CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17-producing T-helper cells in this common autoimmune thyroid disorder.
AIM
The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT.
MATERIALS AND METHODS
Cytokine concentrations were measured in 48 patients with overt ( = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay.
RESULTS
The serum levels of IL-17 were significantly higher in patients than controls ( = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls.
CONCLUSION
These results suggest that IL-17 could play some role in the pathogenesis of HT.
背景
CD4 + T细胞在桥本甲状腺炎（HT）的发病机制中起重要作用。然而，关于这种常见自身免疫性甲状腺疾病中新型白细胞介素（IL）-17产生性辅助性T细胞的特征和功能的数据有限。
目的
本研究旨在评估HT患者血清中辅助性T细胞17相关细胞因子的水平。
材料与方法
采用酶联免疫吸附测定法，对48例显性（n = 23）和亚临床甲状腺功能减退症患者（25例）以及35例健康对照者的细胞因子浓度进行了测定。
结果
患者血清IL-17水平显著高于对照组（P = 0.001），而患者与正常对照组之间IL-22和IL-23水平未观察到差异。
结论
这些结果表明IL-17可能在HT的发病机制中起一定作用。
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