Department of Dermatology, Mugla Sitki Kocman University Faculty of Medicine, 48000 Mugla, Turkey.
Department of Internal Medicine, Mugla Sitki Kocman University Faculty of Medicine, Training and Research Hospital, 48000 Mugla, Turkey.
Biomed Res Int. 2018 Jun 5;2018:9548252. doi: 10.1155/2018/9548252. eCollection 2018.
This study aims to assess how mean corpuscular volume (MCV), red cell distribution width (RDW), and thiol-disulphide homeostasis are altered in psoriasis patients. This is a cross-sectional review of 76 healthy volunteers and 87 psoriasis patients who were consecutively admitted to the department of dermatology. Psoriasis patients and healthy controls were statistically similar with respect to age, sex, body mass index, blood pressures, and disease duration ( > 0.05 for all). When compared to healthy controls, psoriasis patients had significantly higher MCV, RDW, C-reactive protein (CRP), disulphide, disulphide/native thiol, and disulphide/total thiol ( < 0.001 for all). However, psoriasis patients had significantly lower native thiol and native thiol/total thiol ( = 0.009 and < 0.001, respectively). When compared to healthy controls, the patients with Psoriasis Area Severity Index (PASI) ≤ 10 and patients with PASI > 10 had significantly higher MCV, disulphide, disulphide/native thiol, and disulphide/total thiol ( < 0.001 for all). The patients with PASI ≤ 10 and patients with PASI > 10 had significantly lower native thiol/native thiol than healthy controls ( < 0.001 for all). The psoriasis patients with PASI > 10 had significantly higher RDW and CRP than healthy controls and patients with PASI ≤ 10 ( < 0.001 for all). Disulphide, disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol correlate significantly with both PASI scores and disease duration. Thiol-disulphide homeostasis is enhanced in psoriasis patients. Ongoing inflammation and increased oxidative stress in psoriasis patients also trigger the formation of prooxidants which are neutralized by antioxidants such as thiols. That is why plasma thiol levels are decreased in psoriasis patients.
这项研究旨在评估平均红细胞体积（MCV）、红细胞分布宽度（RDW）和硫醇-二硫键动态平衡在银屑病患者中的变化。这是对 76 名健康志愿者和 87 名连续被收入皮肤科的银屑病患者进行的横断面回顾性研究。银屑病患者和健康对照组在年龄、性别、体重指数、血压和疾病持续时间方面统计学上相似（所有 P > 0.05）。与健康对照组相比，银屑病患者的 MCV、RDW、C 反应蛋白（CRP）、二硫键、二硫键/天然巯基和二硫键/总巯基明显升高（所有 P < 0.001）。然而，银屑病患者的天然巯基和天然巯基/总巯基明显降低（分别为 P = 0.009 和 P < 0.001）。与健康对照组相比，PASI 评分≤10 分的患者和 PASI > 10 分的患者的 MCV、二硫键、二硫键/天然巯基和二硫键/总巯基明显升高（所有 P < 0.001）。PASI 评分≤10 分的患者和 PASI > 10 分的患者的天然巯基/天然巯基明显低于健康对照组（所有 P < 0.001）。PASI > 10 分的银屑病患者的 RDW 和 CRP 明显高于健康对照组和 PASI 评分≤10 分的患者（所有 P < 0.001）。二硫键、二硫键/天然巯基、二硫键/总巯基和天然巯基/总巯基与 PASI 评分和疾病持续时间均显著相关。银屑病患者的硫醇-二硫键动态平衡增强。银屑病患者持续的炎症和氧化应激增加也会触发前氧化剂的形成，这些前氧化剂被抗氧化剂如巯基中和。这就是为什么银屑病患者的血浆巯基水平降低的原因。
