Institute for Biological Instrumentation, Russian Academy of Science, Pushchino, Moscow Region, 142290, Russia.
Appl Microbiol Biotechnol. 2018 Sep;102(17):7293-7308. doi: 10.1007/s00253-018-9194-z. Epub 2018 Jul 2.
Laboratory-scale bioreactors represent an important part of microbiological, biotechnological, and biochemical researches. The small volume bioreactors enable the biomass growth, extracellular metabolite production, solid-state fermentation, and biocatalytic processes in a controlled open system. Using the lab-scale bioreactors, the processes which were optimized in experiments can be scaled up to a pilot level. In turn, the manufacturing scale processes can be scaled down to study the heterogeneity of the system and its effect on the producer. This mini-review is focused on a short description of features of the most popular designs of continuous and semi-continuous bioreactors applied at the present time as well as their application area.
实验室规模的生物反应器是微生物学、生物技术和生物化学研究的重要组成部分。小体积生物反应器能够在可控的开放系统中实现生物量生长、细胞外代谢产物生产、固态发酵和生物催化过程。通过使用实验室规模的生物反应器，可以将在实验中优化的过程放大到中试规模。反过来，制造规模的过程可以缩小到研究系统的异质性及其对生产者的影响。本综述简要介绍了目前应用的最受欢迎的连续和半连续生物反应器设计的特点及其应用领域。
