Bioreactors in solid state fermentation technology: Design, applications and engineering aspects.

In recent years, substantial credibility in employing Solid-State Fermentation (SSF) technique has been witnessed owing to its numerous advantages over submerged fermentation (SmF). In spite of enormous advantages, true potential of SSF technology has not been fully realized at industrial scale. The lack of rational and scalable bioreactor designs backed by mathematical models and automated control system that could successfully address heterogeneity with respect to heat and mass, and also operate aseptically, remains the prime reason for it. As a result, there still exists vast scope in SSF bioreactor research and development to facilitate broad spectrum of biotechnological applications. The present article reviews state-of-the-art in SSF technology with focus on bioreactors that have been employed for bioprocess applications, in particular, enzyme production. Based on the mode of operation, bioreactors are divided into four categories with emphasis on design features, effect of operating conditions on productivity, applications and limitations. Selected modeling studies developed over the years, have been revised and presented in problem specific manner in order to address the limitations. Some interesting designs including few recent ones that have been proposed and/or employed at pilot and industrial levels are discussed in more detail.