Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Arch Womens Ment Health. 2019 Feb;22(1):85-91. doi: 10.1007/s00737-018-0883-5. Epub 2018 Jul 3.
Scarce data exists regarding the prevalence of antenatal depression in hospitalized pregnant women, and its effect on perinatal outcome. We aimed to estimate the risk of maternal depression among women hospitalized in a high-risk pregnancy department, and to evaluate its potential association with adverse perinatal outcome. A depression screening self-questionnaire-based prospective study was performed, in which hospitalized pregnant women who screened positive for depression were compared to those who screened negative. The Edinburgh Postnatal Depression Scale (EPDS) was used for antenatal depression screening. Pregnancy course and perinatal outcome were compared between the groups. A multivariate logistic regression model was constructed to control for clinically relevant confounders. During the study period, 279 women met the inclusion criteria. Among them, 28.3% (n = 79) screened positive for depression (≥ 10 points on the EPDS). In the univariate analysis, a significantly higher incidence of preterm delivery (< 37 weeks), low birthweight (< 2500 g), low Apgar scores (at 1 and 5 min), and neonatal intensive care unit (NICU) admissions were noted among the screen positive group. In the multivariate regression model, controlled for maternal age, ethnicity, gestational diabetes mellitus, preeclampsia, past preterm delivery, and gestational age upon admission, maternal antenatal depression during hospitalization was noted as an independent risk factor for preterm delivery (adjusted OR 3.32, 95%CI 1.16-9.52, p = 0.026). Maternal antenatal depression during hospitalization is very common and appears to play a significant and independent role in the prediction of preterm delivery.
关于产前抑郁症在住院孕妇中的流行率及其对围产期结局的影响，相关数据十分匮乏。我们旨在评估高危妊娠科住院孕妇中抑郁的风险，并评估其与不良围产期结局的潜在关联。本研究采用基于抑郁筛查自评问卷的前瞻性研究方法，对筛查出患有抑郁症的住院孕妇与筛查结果阴性的孕妇进行比较。采用爱丁堡产后抑郁量表（EPDS）进行产前抑郁筛查。比较两组孕妇的妊娠过程和围产期结局。构建多变量逻辑回归模型以控制临床相关混杂因素。在研究期间，共有 279 名符合纳入标准的孕妇。其中，28.3%（n=79）筛查出患有抑郁症（EPDS 评分≥10 分）。在单因素分析中，筛查阳性组的早产（<37 周）、低出生体重（<2500g）、低 Apgar 评分（1 分钟和 5 分钟）和新生儿重症监护病房（NICU）入住率显著更高。在多变量回归模型中，控制了母亲的年龄、种族、妊娠期糖尿病、子痫前期、既往早产和入院时的孕周，住院期间母亲产前抑郁被认为是早产的独立危险因素（调整后的 OR 3.32，95%CI 1.16-9.52，p=0.026）。住院期间孕妇的产前抑郁非常普遍，似乎在预测早产方面起着显著和独立的作用。
