Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Curr Cancer Drug Targets. 2019;19(5):360-367. doi: 10.2174/1568009618666180703154233.
Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.
多倍体与细胞体积增大有关，常见于成人器官的一部分和人类胚胎的卵裂球阶段。多倍体通过内复制或细胞融合形成，以支持包括早期胚胎发生在内的特定发育需求。最近的数据表明，多倍体巨癌细胞 (PGCC) 可能在应对致癌和治疗压力时获得了激活的早期胚胎样程序，从而产生了具有耐药性和转移能力的重编程癌细胞。针对 PGCC 可能为癌症治疗开辟新的机会。
